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Tacrolimus and mycophenolate regimen and subclinical tubulo-interstitial inflammation in low immunological risk renal transplants
- Source :
- Transplant International. 30
- Publication Year :
- 2017
- Publisher :
- Frontiers Media SA, 2017.
-
Abstract
- The aim was to evaluate the relationship between maintenance immunosuppression, subclinical tubulo-interstital inflammation and interstitial fibrosis/tubular atrophy (IF/TA) in surveillance biopsies performed in low immunological risk renal transplants at two transplant centers. The Barcelona cohort consisted of 109 early and 66 late biopsies in patients receiving high tacrolimus (TAC-C0 target at 1-year 6-10 ng/mL) and reduced MMF dose (500 mg bid at 1-year). The Oslo cohort consisted of 262 early and 237 late biopsies performed in patients treated with low TAC-C0 (target 3-7 ng/mL) and standard MMF dose (750 mg bid). Subclinical inflammation, adjusted for confounders, was associated with low TAC-C0 in the early (OR: 0.75, 95%CI: 0.61-0.92; p=0.006) and late biopsies (OR: 0.69, 95%CI: 0.50-0.95; p=0.023) from Barcelona. In the Oslo cohort, it was associated with low MMF in early biopsies (OR: 0.90, 95%CI: 0.83-0.98; p=0.0101) and with low TAC-C0 in late biopsies (OR: 0.77, 95%CI: 0.61-0.97; p=0.0286). MMF dose was significantly reduced in Oslo between early and late biopsies. IF/TA was not associated with TAC-C0 or MMF dose in the multivariate analysis. Our data suggest that in TAC and MMF based regimens, TAC-C0 levels are associated with subclinical inflammation in patients receiving reduced MMF dose. This research has been accepted and published in Transplant International. © 2017 Wiley
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
030232 urology & nephrology
030230 surgery
Kidney
Gastroenterology
Mycophenolic acid
Tacrolimus
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
Internal medicine
Medicine
Humans
Kidney transplantation
Subclinical infection
Aged
Immunosuppression Therapy
Transplantation
business.industry
Immunosuppression
Middle Aged
Mycophenolic Acid
medicine.disease
Kidney Transplantation
Surgery
Regimen
Cohort
Nephritis, Interstitial
Female
business
medicine.drug
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 09340874
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Transplant International
- Accession number :
- edsair.doi.dedup.....fc6be5e720f5311b2348463ba2090c32
- Full Text :
- https://doi.org/10.1111/tri.13002