Examination of β-TCP/collagen composite in bone defects without periosteum in dogs: a histological and cast model evaluation

After tooth extraction, the alveolar ridge is absorbed and changes shape. Recently, socket preservation has been proposed to prevent alveolar ridge absorption. However, there are few reports of socket preservation in a model without the periosteum, and alveolar bone regeneration and resorption inhibitory effects in this type of model remain unclear. Therefore, in this study, we conducted socket preservation at the bone defect without the periosteum using a canine model. Ten beagle dogs were extracted. A 5 mm × 7 mm × 4 mm bone defect was created without the periosteum. Defects were filled with beta-tricalcium phosphate (β-TCP)/collagen (Col), β-TCP, collagen, or left intact (Control). The observation periods were 4 and 8 weeks (n = 5 per group). Evaluations were made of the newly formed bone area, residual granular area, horizontal width and vertical dimensional change. The newly formed bone area at 4 weeks after surgery in TCP/Col, Collagen, β-TCP, and Control groups was 21.50%, 17.26%, 18.22%, and 17.47%. Compared to the control group, the TCP/Col group showed a significant difference in bone regeneration and horizontal width. TCP/Col is suggested to be effective for bone regeneration and suppression of alveolar ridge resorption in the bone defect periosteum removal model.