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The Influence of Virus Infection on Microglia and Accelerated Brain Aging
- Source :
- Cells, Vol 10, Iss 1836, p 1836 (2021), Cells
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infections affect the brain and interfere with microglia functions, including human immune deficiency virus, flaviviruses, SARS-CoV-2, influenza, and human herpes viruses. Especially chronic viral infections causing low-grade neuroinflammation may contribute to brain aging. This review elucidates the potential role of various neurotropic viruses in microglia-driven neurocognitive deficiencies and possibly accelerated brain aging.
- Subjects :
- 0301 basic medicine
Aging
human herpes virus
QH301-705.5
viruses
Central nervous system
microglia
Inflammation
Disease
Review
Virus
neuroinflammation
03 medical and health sciences
0302 clinical medicine
Immune system
flavivirus
medicine
Animals
Humans
Biology (General)
Neuroinflammation
Neurotropic virus
Microglia
business.industry
SARS-CoV-2
Brain
COVID-19
HIV
General Medicine
neurotropic virus
030104 developmental biology
medicine.anatomical_structure
Virus Diseases
Immunology
brain aging
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 10
- Issue :
- 1836
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....fc8c803be99f355fe467c5386bddf15d