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The Influence of Virus Infection on Microglia and Accelerated Brain Aging

Authors :
Alexey Larionov
Nils Lannes
Luis Filgueira
Source :
Cells, Vol 10, Iss 1836, p 1836 (2021), Cells
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Microglia are the resident immune cells of the central nervous system contributing substantially to health and disease. There is increasing evidence that inflammatory microglia may induce or accelerate brain aging, by interfering with physiological repair and remodeling processes. Many viral infections affect the brain and interfere with microglia functions, including human immune deficiency virus, flaviviruses, SARS-CoV-2, influenza, and human herpes viruses. Especially chronic viral infections causing low-grade neuroinflammation may contribute to brain aging. This review elucidates the potential role of various neurotropic viruses in microglia-driven neurocognitive deficiencies and possibly accelerated brain aging.

Details

Language :
English
ISSN :
20734409
Volume :
10
Issue :
1836
Database :
OpenAIRE
Journal :
Cells
Accession number :
edsair.doi.dedup.....fc8c803be99f355fe467c5386bddf15d