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Assessment of ISGLS Definition of Posthepatectomy Liver Failure and Its Effect on Outcome in Patients with Hepatocellular Carcinoma
- Source :
- Journal of Gastrointestinal Surgery. 18:729-736
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Posthepatectomy liver failure (PHLF) is a major complication after hepatectomy. As there was no standardized definition, the International Study Group of Liver Surgery (ISGLS) defined PHLF as increased international normalized ratio and hyperbilirubinemia on or after postoperative day 5 in 2010. We evaluated the impact of the ISGLS definition of PHLF on hepatocellular carcinoma (HCC) patients. We retrospectively analyzed 210 consecutive HCC patients who underwent curative hepatectomy at our facility from 2005 to 2010. The median follow-up period after hepatectomy was 35.2 months. Thirty-nine (18.6 %) patients fulfilled the ISGLS definition of PHLF. Overall survival (OS) rates at 1, 3, and 5 years in patients with/without PHLF were 69.1/93.5, 45.1/72.5, and 45.1/57.8 %, respectively (P = 0.002). Recurrence-free survival (RFS) rates at 1, 3, and 5 years in patients with/without PHLF were 40.9/65.9, 15.7/38.3, and 15.7/20.3 %, respectively (P = 0.003). Multivariate analysis revealed that PHLF was significantly associated with both OS (P = 0.047) and RFS (P = 0.019). Extent of resection (P
- Subjects :
- Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Carcinoma, Hepatocellular
Multivariate analysis
medicine.medical_treatment
Blood Loss, Surgical
Gastroenterology
Disease-Free Survival
Risk Factors
Terminology as Topic
Internal medicine
medicine
Carcinoma
Hepatectomy
Humans
In patient
Hospital Mortality
International Normalized Ratio
Survival rate
Aged
Hyperbilirubinemia
Retrospective Studies
Aged, 80 and over
business.industry
Incidence (epidemiology)
Liver Neoplasms
Retrospective cohort study
Length of Stay
Middle Aged
medicine.disease
Survival Rate
Treatment Outcome
Hepatocellular carcinoma
Female
Surgery
business
Liver Failure
Follow-Up Studies
Subjects
Details
- ISSN :
- 18734626 and 1091255X
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Gastrointestinal Surgery
- Accession number :
- edsair.doi.dedup.....fc9c8b21415938b3e15a0e1aa8743965
- Full Text :
- https://doi.org/10.1007/s11605-013-2423-y