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WRAP53 beta, survivin and p16(INK4a) expression as potential predictors of radiotherapy/chemoradiotherapy response in T2N0-T3N0 glottic laryngeal cancer
- Source :
- Oncology Reports
- Publication Year :
- 2017
- Publisher :
- Linköpings universitet, Avdelningen för cellbiologi, 2017.
-
Abstract
- The current treatment recommendation for T2-3N0M0 glottic squamous cell carcinoma (SCC) in the Nordic countries comprises of radiotherapy (RT) and chemoradiotherapy (CRT). Tumor radiosensitivity varies and another option is primary surgical treatment, which underlines the need for predictive markers in this patient population. The aim of the present study was to investigate the relation of the proteins WRAP53 beta, survivin and p16INK4a to RT/CRT response and ultimate outcome of patients with T2-T3N0 glottic SCC. Protein expression was determined using immunohistochemistry on tumors from 149 patients consecutively treated with RT or CRT at Helsinki University Hospital, Karolinska University Hospital, and Linkping University Hospital during 1999-2010. Our results demonstrate a significantly better 5-year relapse-free survival, disease-free survival (DFS), disease-specific survival and overall survival of patients with T3N0 tumors treated with CRT compared with RT alone. Patients with tumors showing a cytoplasmic staining of WRAP53 beta revealed significantly worse DFS compared with those with nuclear staining. For survivin, we observed a trend towards better 5-year DFS in patients with strong nuclear survivin expression compared with those with weak nuclear survivin expression (p=0.091). Eleven (7%) tumors showed p16 positivity, with predilection to younger patients, and this age group of patients with p16-positive SCC had a significantly better DFS compared with patients with p16-negative SCC. Taken together, our results highlight WRAP53 beta as a potential biomarker for predicting RT/CRT response in T2-T3N0 glottic SCC. p16 may identify a small but distinct group of glottic SCC with favorable outcome. Furthermore, for T3N0 patients better outcome was observed following CRT compared to RT alone. Funding Agencies|Swedish Cancer Society [2010/545]; County Council of Ostergotland; Research Funds of Linkoping University Hospital; Finnish Cancer Society; Finnish Medical Foundation; Finnish-Norwegian Medical Foundation; Helsinki University Hospital Research Funds [TYH2015204]
- Subjects :
- Male
0301 basic medicine
Oncology
Cancer Research
Survivin
medicine.medical_treatment
p16
Inhibitor of Apoptosis Proteins
chemoradiotherapy
0302 clinical medicine
WRAP53β
Telomerase
Articles
General Medicine
Middle Aged
Laryngeal Neoplasm
Immunohistochemistry
3. Good health
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
biomarker
population characteristics
Female
Glottis
medicine.medical_specialty
recurrence
Antineoplastic Agents
survival
03 medical and health sciences
Predictive Value of Tests
Internal medicine
Biomarkers, Tumor
otorhinolaryngologic diseases
medicine
Carcinoma
Humans
neoplasms
Laryngeal Neoplasms
Cyclin-Dependent Kinase Inhibitor p16
radiotherapy
Neoplasm Staging
Squamous Cell Carcinoma of Head and Neck
business.industry
Kirurgi
Head and neck cancer
Cancer
medicine.disease
Glottic Squamous Cell Carcinoma
Radiation therapy
stomatognathic diseases
head and neck cancer
WRAP53 beta
survivin
030104 developmental biology
Surgery
Cisplatin
business
Chemoradiotherapy
Molecular Chaperones
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Oncology Reports
- Accession number :
- edsair.doi.dedup.....fca3f76f8798e4abe70bbac73f11546b