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Cross-sectional associations between angiotensin-converting enzyme inhibitor use and cancer diagnosis in US adults
- Source :
- CLINICAL AND EXPERIMENTAL MEDICINE, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname, Clinical and Experimental Medicine, Clinical and Experimental Medicine, Springer Verlag, 2020, 20 (3), pp.409-416. ⟨10.1007/s10238-020-00622-7⟩, r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, Fundació Sant Joan de Déu
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- The objective of the present study was to investigate the association between angiotensin-converting enzyme (ACE) inhibitor use and cancer incidence (overall, and breast, prostate, and colorectal cancers specifically) in a large representative sample of US adults. Cross-sectional data on cancer diagnosis, timing of cancer diagnosis, ACE inhibitor use, and other characteristics were extracted from 49 512 adults aged ≥ 20years participating in the National Health and Nutrition Examination Survey (1999–2016). Multivariable-logistic and propensity score matching (PSM) regressions examined the relationship between pre-diagnosis use of ACE inhibitors and diagnosis of all cancers, and breast, prostate, and colorectal cancers specifically. Overall, we observed an increased likelihood of cancer diagnosis [odds ratio (OR) 1.269, 95% confidence interval (CI) 1.088–1.480] among those who used ACE inhibitors compared to non-ACE inhibitor use, and for prostate cancer diagnosis (OR 1.438, 95% CI 1.090–1.897), after adjusting for age, sex, body mass index, race/ethnicity, educational attainment, physical activity, alcohol drinking status, smoking status, and high blood pressure. PSM regression retrieved more conservative estimates such that the increased likelihood of cancer diagnosis was only observed when comparing ACE inhibitor users with non-drug users (OR 1.022, 95% CI 1.016–1.027). Compared with non-ACE inhibitor use, ACE inhibitor use was associated with an increased risk of prostate cancer. In conclusion, in this large representative sample of US adults, it was found that ACE inhibitor use may have a marginal influence on some cancers. © 2020, Springer Nature Switzerland AG.
- Subjects :
- Male
0301 basic medicine
Oncology
Epidemiology
[SDV]Life Sciences [q-bio]
Angiotensin-Converting Enzyme Inhibitors
Angiotensin-converting enzyme inhibitors, Cancer · Epidemiology, NHANES · Observational
Prostate cancer
0302 clinical medicine
Risk Factors
Surveys and Questionnaires
Observational
Cancer
Aged, 80 and over
2. Zero hunger
biology
Incidence
General Medicine
Middle Aged
3. Good health
030220 oncology & carcinogenesis
Female
Colorectal Neoplasms
medicine.drug
Adult
medicine.medical_specialty
National Health and Nutrition Examination Survey
Breast Neoplasms
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Internal medicine
medicine
NHANES
Humans
Aged
business.industry
Prostatic Neoplasms
Angiotensin-converting enzyme
Odds ratio
Angiotensin-converting enzyme inhibitors, Cancer, Epidemiology, NHANES, Observational
medicine.disease
United States
Cross-Sectional Studies
Logistic Models
030104 developmental biology
Propensity score matching
ACE inhibitor
biology.protein
business
Body mass index
Subjects
Details
- ISSN :
- 15919528 and 15918890
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Medicine
- Accession number :
- edsair.doi.dedup.....fca472ef1c94ff7c3df6239d56a7a73b