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Role of ATP in Extracellular Vesicle Biogenesis and Dynamics
- Source :
- Frontiers in Pharmacology, Frontiers in Pharmacology, Vol 12 (2021)
- Publication Year :
- 2021
-
Abstract
- Adenosine triphosphate (ATP) is among the molecules involved in the immune response. It acts as danger signal that promotes inflammation by activating both P2X and P2Y purinergic receptors expressed in immune cells, including microglia, and tumor cells. One of the most important receptors implicated in ATP-induced inflammation is P2X7 receptor (P2X7R). The stimulation of P2X7R by high concentration of ATP results in cell proliferation, inflammasome activation and shedding of extracellular vesicles (EVs). EVs are membrane structures released by all cells, which contain a selection of donor cell components, including proteins, lipids, RNA and ATP itself, and are able to transfer these molecules to target cells. ATP stimulation not only promotes EV production from microglia but also influences EV composition and signaling to the environment. In the present review, we will discuss the current knowledge on the role of ATP in the biogenesis and dynamics of EVs, which exert important functions in physiology and pathophysiology.
- Subjects :
- Mini Review
tumor cells
Inflammation
NO
chemistry.chemical_compound
immune cells
ATP cargo
medicine
Pharmacology (medical)
Receptor
Pharmacology
extracellular vesicle biogenesis
Microglia
Chemistry
ATP
extracellular vesicle morphology
extracellular vesicles
P2X7 receptor
Purinergic receptor
lcsh:RM1-950
Inflammasome
Extracellular vesicle
Cell biology
medicine.anatomical_structure
lcsh:Therapeutics. Pharmacology
medicine.symptom
Adenosine triphosphate
Biogenesis
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Frontiers in Pharmacology, Frontiers in Pharmacology, Vol 12 (2021)
- Accession number :
- edsair.doi.dedup.....fcafb71b4b288ababec92a8c83751268