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Polymorphism in tumor necrosis factor genes associated with myasthenia gravis
- Source :
- Journal of Neuroimmunology. 88:137-143
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- The aim of this study was to analyze associations between myasthenia gravis (MG) and polymorphisms in the tumor necrosis factor (TNF) region in 79 Swedish patients and 155 unrelated controls. The frequency of the TNFa2 allele of a microsatellite located 3.5 kb upstream of the lymphotoxin alpha (LT- α ) gene in the TNF region was found to be increased in overall MG patients compared to controls. The frequency of the short 5.5 kb fragment (TNFB*1) of a bi-allelic Nco I RFLP polymorphism located at the first intron of the LT- α gene was increased in patients with an early onset of disease compared to patients with a later onset.
- Subjects :
- Lymphotoxin alpha
Immunology
Human leukocyte antigen
Reference Values
Polymorphism (computer science)
Myasthenia Gravis
medicine
Humans
Immunology and Allergy
Age of Onset
Allele
Lymphotoxin-alpha
Alleles
Polymorphism, Genetic
Tumor Necrosis Factor-alpha
business.industry
medicine.disease
Molecular biology
Introns
Peptide Fragments
Myasthenia gravis
Lymphotoxin
Neurology
Tumor necrosis factor alpha
Neurology (clinical)
Restriction fragment length polymorphism
business
Polymorphism, Restriction Fragment Length
Microsatellite Repeats
Subjects
Details
- ISSN :
- 01655728
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi.dedup.....fcbbe0a7966f083da6b72386499f781f