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Endothelial PERK-ATF4-JAG1 axis activated by T-ALL remodels bone marrow vascular niche
- Source :
- Theranostics. 12(6)
- Publication Year :
- 2021
-
Abstract
- The endoplasmic reticulum unfolded protein response (UPR) is a conserved adaptive signaling in ER homeostasis and has emerged as critical in highly proliferating cells and potential treatment target for acute T-cell lymphoblastic leukemia (T-ALL).
- Subjects :
- Medicine (miscellaneous)
Endothelial Cells
Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Activating Transcription Factor 4
Mice
eIF-2 Kinase
Bone Marrow
Unfolded Protein Response
Animals
Humans
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Jagged-1 Protein
Subjects
Details
- ISSN :
- 18387640
- Volume :
- 12
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Theranostics
- Accession number :
- edsair.doi.dedup.....fcbda6df5e282b7a0f18dcc75ff18c72