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AllergoOncology - the impact of allergy in oncology: EAACI position paper
- Source :
- Jensen-Jarolim, E, Bax, H J, Bianchini, R, Capron, M, Corrigan, C, Castells, M, Dombrowicz, D, Daniels-Wells, T R, Fazekas, J, Fiebiger, E, Gatault, S, Gould, H J, Janda, J, Josephs, D H, Karagiannis, P, Levi-Schaffer, F, Meshcheryakova, A, Mechtcheriakova, D, Mekori, Y, Mungenast, F, Nigro, E A, Penichet, M L, Redegeld, F, Saul, L, Singer, J, Spicer, J F, Siccardi, A G, Spillner, E, Turner, M C, Untersmayr, E, Vangelista, L & Karagiannis, S N 2017, ' AllergoOncology-the impact of allergy in oncology : EAACI position paper ', Allergy, vol. 72, no. 6, pp. 866-887 . https://doi.org/10.1111/all.13119, Jensen-Jarolim, E, Bax, HJ, Bianchini, R, Capron, M, Corrigan, C, Castells, M, Dombrovicz, D, Daniels-Wells, HR, Fazekas, J, Fiebiger, E, Gatault, S, Gould, H, Janda, J, Josephs, DH, Karagiannis, P, Levi-Schaffer, F, Meshcheryakova, A, Mechtcheriakova, D, Mekori, Y, Mungenast, F, Nigro, EA, Penichet, M F, Redegeld, F, Saul, L, Singer, J, Spicer, JF, Siccardi, AG, Spillner, E, Turner, MC, Untersmayr, E, Vangelista, L & Karagiannis, S N 2017, ' AllergoOncology-the Impact of Allergy in Oncology. EAACI Position Paper. ', Allergy: European Journal of Allergy and Clinical Immunology, vol. 72, no. 6, pp. 866-887 . https://doi.org/10.1111/all.13119
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment.
- Subjects :
- AllergoOncology
0301 basic medicine
Allergy
Immunology
Inflammation
Immunoglobulin E
medicine.disease_cause
Clinical oncology
Antibodies
Article
Atopy
03 medical and health sciences
Th2 Cells
Immune system
Neoplasms
Hypersensitivity
medicine
Humans
Immunology and Allergy
Biologics, desensitization
Immunologic Surveillance
Cancer
Chemotherapeutic
IgG4
Tumor
biology
Effector
business.industry
medicine.disease
3. Good health
030104 developmental biology
Allergic response
biology.protein
Immunotherapy
IgE
medicine.symptom
Antibody
business
Subjects
Details
- ISSN :
- 01054538
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Allergy
- Accession number :
- edsair.doi.dedup.....fcf18818459054d0000c9baa1c732113