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Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial)
- Source :
- Nutrients, Nutrients, 7(11), 8905-8915. Multidisciplinary Digital Publishing Institute (MDPI), Nutrients; Volume 7; Issue 11; Pages: 8905-8915, Volume 7, Issue 11, Pages 8905-8915, Nutrients, Vol 7, Iss 11, Pp 8905-8915 (2015)
- Publication Year :
- 2015
- Publisher :
- MDPI AG, 2015.
-
Abstract
- Coronary artery calcification (CAC) develops early in the pathogenesis of atherosclerosis and is a strong and independent predictor of cardiovascular disease (CVD). Arterial calcification is caused by an imbalance in calcification regulatory mechanisms. An important inhibitor of calcification is vitamin K-dependent matrix Gla protein (MGP). Both preclinical and clinical studies have shown that inhibition of the vitamin K-cycle by vitamin K antagonists (VKA) results in elevated uncarboxylated MGP (ucMGP) and subsequently in extensive arterial calcification. This led us to hypothesize that vitamin K supplementation may slow down the progression of calcification. To test this, we designed the VitaK-CAC trial which analyses effects of menaquinone-7 (MK-7) supplementation on progression of CAC. The trial is a double-blind, randomized, placebo-controlled trial including patients with coronary artery disease (CAD). Patients with a baseline Agatston CAC-score between 50 and 400 will be randomized to an intervention-group (360 microgram MK-7) or a placebo group. Treatment duration will be 24 months. The primary endpoint is the difference in CAC-score progression between both groups. Secondary endpoints include changes in arterial structure and function, and associations with biomarkers. We hypothesize that treatment with MK-7 will slow down or arrest the progression of CAC and that this trial may lead to a treatment option for vascular calcification and subsequent CVD.
- Subjects :
- Adult
Vitamin
medicine.medical_specialty
Pathology
lcsh:TX341-641
Coronary Artery Disease
Article
Pathogenesis
Coronary artery disease
chemistry.chemical_compound
Clinical Protocols
Double-Blind Method
Internal medicine
Matrix gla protein
medicine
Clinical endpoint
Humans
vitamin K2
cardiovascular diseases
menaquinone-7
Extracellular Matrix Proteins
Nutrition and Dietetics
biology
business.industry
Calcium-Binding Proteins
Vitamin K2
nutritional and metabolic diseases
Vitamin K 2
Arteries
Vitamins
vascular calcification
coronary artery calcification
matrix gla protein
medicine.disease
Arterial calcification
chemistry
Research Design
Dietary Supplements
Disease Progression
biology.protein
Cardiology
Calcium
business
lcsh:Nutrition. Foods and food supply
Food Science
Calcification
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....fcf18be9195dfa7549b6c368a6051313