Back to Search
Start Over
Artificial Aquaporin That Restores Wound Healing of Impaired Cells
- Source :
- Journal of the American Chemical Society. 142:15638-15643
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- Artificial aquaporins are synthetic molecules that mimic the structure and function of natural aquaporins (AQPs) in cell membranes. The development of artificial aquaporins would provide an alternative strategy for treatment of AQP-related diseases. In this report, an artificial aquaporin has been constructed from an amino-terminated tubular molecule, which operates in a unimolecular mechanism. The artificial channel can work in cell membranes with high water permeability and selectivity rivaling those of AQPs. Importantly, the channel can restore wound healing of the cells that contain function-lost AQPs.
- Subjects :
- Models, Molecular
Wound Healing
Molecular Structure
urogenital system
Chemistry
Aquaporin
Hep G2 Cells
General Chemistry
Molecular Dynamics Simulation
Aquaporins
010402 general chemistry
01 natural sciences
Biochemistry
Single Molecule Imaging
Catalysis
0104 chemical sciences
Cell biology
Structure and function
Colloid and Surface Chemistry
Membrane
Human Umbilical Vein Endothelial Cells
Humans
Wound healing
Alternative strategy
Subjects
Details
- ISSN :
- 15205126 and 00027863
- Volume :
- 142
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....fd046554fe71d52b541d2f4d19149c79