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N-myc suppression and cell cycle arrest at G1 phase by prostaglandins
- Source :
- FEBS Letters. (1-2):15-18
- Publisher :
- Published by Elsevier B.V.
-
Abstract
- Effects of cyclopentenone prostaglandins, delta 12-prostaglandin (PG) J2 and PGA2 on the expression of N-myc in relation to the effects on cell cycle progression were investigated using human neuroblastoma cell line GOTO. Both PGs suppressed N-myc expression within several hours prior to inducing G1 arrest. The N-myc suppression with delta 12-PGJ2 was continued but with PGA2 it was gradually released, followed by the release of G1 arrest. These results suggest that delta 12-PGJ2 and PGA2 inhibit cell cycle progression in strong association with N-myc suppression and delta 12-PGJ2 is more potent and has a longer effect than PGA2.
- Subjects :
- Cell cycle checkpoint
Biophysics
Genes, myc
Prostaglandin
Biology
Cell cycle
Biochemistry
Flow cytometry
Proto-Oncogene Proteins c-myc
chemistry.chemical_compound
Neuroblastoma
Suppression, Genetic
Structural Biology
Prostaglandins, Synthetic
Genetics
medicine
Tumor Cells, Cultured
Humans
Northern blot
RNA, Messenger
Prostaglandin a
Molecular Biology
Cyclopentenone prostaglandins
Prostaglandin A2 N-myc
Prostaglandins A
Δ12-Prostaglandin J2
medicine.diagnostic_test
Prostaglandin D2
Human neuroblastoma cell
Cell Biology
medicine.disease
chemistry
Gene Expression Regulation
Cancer research
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....fd3672df2034cb98ab840544926586eb
- Full Text :
- https://doi.org/10.1016/0014-5793(90)81224-C