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Nucleolar and spindle-associated protein 1 is a tumor grade correlated prognosis marker for glioma patients
- Source :
- CNS Neuroscience & Therapeutics. 24:178-186
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Aims Despite therapeutic advances in glioma management including surgery, radiation, and chemotherapy, the improvement of patient outcome is far from satisfactory. Nucleolar and spindle-associated protein 1 (NUSAP1) is an important functional protein during mitosis, and its abnormal expression is implicated in progression of different types of tumors. However, the role of NUSAP1 in gliomas remains unclear. Methods NUSAP1 expression in gliomas with different grades was investigated based on GEO glioma datasets. Kaplan-Meier survival analysis was used to evaluate its prognostic significance. In vitro assays were also performed to evaluate effects of NUSAP1 on malignant phenotypes of glioma cells by silencing NUSAP1. Results NUSAP1 expression was correlated not only with glioma grade but also with prognosis of glioma patients. NUSAP1 depletion suppressed proliferation of U251 cells by inducing cell cycle arrest at G2/M phase and apoptosis. NUSAP1 depletion rendered U251 cells impaired migratory ability as well. Conclusion NUSAP1 is a potential prognosis marker for glioma patients and therapeutic strategies targeting NUSAP1 might hold promise in improving glioma treatment.
- Subjects :
- Adult
Male
0301 basic medicine
Cell cycle checkpoint
medicine.medical_treatment
Apoptosis
03 medical and health sciences
0302 clinical medicine
Cell Movement
Cell Line, Tumor
Physiology (medical)
Glioma
Biomarkers, Tumor
medicine
Humans
Gene silencing
Pharmacology (medical)
RNA, Messenger
neoplasms
Mitosis
Survival analysis
Cell Proliferation
Pharmacology
Chemotherapy
Brain Neoplasms
business.industry
Cell Cycle
Original Articles
Middle Aged
Prognosis
medicine.disease
Phenotype
nervous system diseases
Psychiatry and Mental health
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
Female
business
Microtubule-Associated Proteins
Subjects
Details
- ISSN :
- 17555930
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- CNS Neuroscience & Therapeutics
- Accession number :
- edsair.doi.dedup.....fd4594ea2c556f06f57eee8ab98ae8a0