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Fat mass and vascular health in overweight/obese children
- Publication Year :
- 2021
-
Abstract
- Childhood obesity is one of the most serious public health challenges of the 21st century. Body mass index (BMI), the most widely used marker of body fatness, has serious limitations, particularly in children, since it does not accurately discriminate between lean and fat mass. Aim of our study was to investigate if the estimate of fat mass, as derived by a new prediction model, was associated with carotid intima media thickness (IMT) and the cross-sectional area of the intima media complex (CSA-IMC) in overweight or obese children.As many as 375 overweight/obese Italian children, 54.7% males, aged 5-15 years, admitted to a tertiary care hospital, were consecutively enrolled in a study on cardiovascular markers of atherosclerosis. All children underwent an ultrasound carotid examination. Mean weight was 62.2 ± 20.8 Kg and fat-mass was 26.2 ± 10.7 Kg. Multiple regression analyses showed a significant association of fat mass with carotid IMT (β 0.156, p 0.01) and CSA-IMC (β 0.216, p 0.001); these associations remained significant after controlling for the main cardiovascular risk factors (age, sex, blood pressure, HOMA-index, triglycerides, LDL-cholesterol, HDL-cholesterol, birth weight and high-sensitivity C-reactive protein).Fat mass calculated with the new formula is independently associated with subclinical atherosclerosis in overweight/obese children.
- Subjects :
- Carotid Artery Diseases
Male
Pediatric Obesity
Atherosclerosis
Carotid IMT
Children
Obesity
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Predictive Value of Test
030204 cardiovascular system & hematology
Carotid imt
Overweight
Carotid Intima-Media Thickness
0302 clinical medicine
Risk Factors
Age Factor
Child
Adiposity
Nutrition and Dietetics
Age Factors
Prognosis
Italy
Atherosclerosi
Child, Preschool
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
Human
medicine.medical_specialty
Adolescent
Prognosi
030209 endocrinology & metabolism
Risk Assessment
Models, Biological
Childhood obesity
Fat mass
03 medical and health sciences
Predictive Value of Tests
Internal medicine
Carotid Intima-Media Thickne
medicine
Humans
Carotid Artery Disease
business.industry
Public health
Risk Factor
medicine.disease
Intima-media thickness
business
Body mass index
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....fd77731c90304164043ec6c461789f08