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Nidogen Plays a Role in the Regenerative Axon Growth of Adult Sensory Neurons Through Schwann Cells
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2009
- Publisher :
- Korean Academy of Medical Sciences, 2009.
-
Abstract
- We previously reported that nidogen is an extracellular matrix protein regulating Schwann cell proliferation and migration. Since Schwann cells play a critical role in peripheral nerve regeneration, nidogen may play a role in it via regulation of Schwann cells. Here, we demonstrate direct evidence that nidogen induces elongation of regenerative axon growth of adult sensory neurons, and that the effect is Schwann cell dependent. Continuous infusion of recombinant ectodomain of tumor endothelial marker 7, which specifically blocks nidogen function in Schwann cells, suppressed regenerative neurite growth in a sciatic nerve axotomy model. Taken together, it is likely that nidogen is required for proper regeneration of peripheral nerves after injury.
- Subjects :
- Male
endocrine system
animal structures
Sensory Receptor Cells
Neurite
medicine.medical_treatment
Schwann cell
Nerve Tissue Proteins
Biology
Schwann cell proliferation
Rats, Sprague-Dawley
Dorsal root ganglion
Cell Movement
Neurites
medicine
Regeneration
Animals
Nidogen
Cell Proliferation
Membrane Glycoproteins
Dorsal Root Ganglion
Regeneration (biology)
Membrane Proteins
Axotomy
General Medicine
Recombinant Proteins
Nerve Regeneration
Rats
Cell biology
medicine.anatomical_structure
nervous system
Ectodomain
Immunology
Original Article
Schwann Cells
Sciatic nerve
Tumor Endothelial Marker 7
Subjects
Details
- ISSN :
- 10118934
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....fd87305f276dfa397e8910060e79c8fa
- Full Text :
- https://doi.org/10.3346/jkms.2009.24.4.654