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Neurobiological and clinical effect of metacognitive interpersonal therapy vs structured clinical model: study protocol for a randomized controlled trial
- Source :
- BMC Psychiatry, Vol 19, Iss 1, Pp 1-11 (2019), BMC Psychiatry
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background Borderline Personality Disorder (BPD) is a complex and debilitating disorder, characterized by deficits in metacognition and emotion dysregulation. The “gold standard” treatment for this disorder is psychotherapy with pharmacotherapy as an adjunctive treatment to target state symptoms. The present randomized clinical trial aims to assess the clinical and neurobiological changes following Metacognitive Interpersonal Therapy (MIT) compared with Structured Clinical Management (SCM) derived from specific recommendations in APA (American Psychiatric Association) guidelines for BPD. Methods The study design is a randomized parallel controlled clinical trial and will include 80 BPD outpatients, aged 18–45 enrolled at 2 recruitment centers. Primary outcome will be the clinical change in emotion regulation capacities assessed with the Difficulties in Emotion Regulation Scale (DERS). We will also investigated the effect of psychotherapy on metacognitive abilities and several clinical features such as BPD symptomatology, general psychopathology, depression, personal functioning, and trait dimensions (anger, impulsivity, alexithymia). We will evaluate changes in brain connectivity patterns and during the view of emotional pictures. A multidimensional assessment will be performed at the baseline, at 6, 12, 18 months. We will obtain structural and functional Magnetic Resonance Images (MRIs) in MIT-Treated BPD (N = 30) and SCM-treated BPD (N = 30) at baseline and after treatment, as well as in a group of 30 healthy and unrelated volunteers that will be scanned once for comparison. Discussion The present study could contribute to elucidate the neurobiological mechanisms underlying psychotherapy efficacy. The inclusion of a multidisciplinary study protocol will allow to study BPD considering different features that can affect the treatment response and their reciprocal relationships. Trial registration NCT02370316. Registered 02/24/2015. Electronic supplementary material The online version of this article (10.1186/s12888-019-2127-2) contains supplementary material, which is available to authorized users.
- Subjects :
- Adult
Male
Adolescent
lcsh:RC435-571
Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA
medicine.medical_treatment
Neuroimaging
Impulsivity
law.invention
Study Protocol
Young Adult
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Alexithymia
law
Emotionality
lcsh:Psychiatry
mental disorders
medicine
Humans
030212 general & internal medicine
Borderline personality disorder
Interpersonal Psychotherapy
Emotion dysregulation
Metacognition
Psychotherapy
business.industry
Borderline Personality Disorder
Female
Middle Aged
Treatment Outcome
medicine.disease
030227 psychiatry
Clinical trial
Cognitive behavioral therapy
Psychiatry and Mental health
Adjunctive treatment
medicine.symptom
business
Clinical psychology
Subjects
Details
- ISSN :
- 1471244X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- BMC Psychiatry
- Accession number :
- edsair.doi.dedup.....fd8ddaf998284feba66e3e6a2230ffc7