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AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer-a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)
- Source :
- Clinical and Translational Allergy, Vol 10, Iss 1, Pp 1-16 (2020), Clinical and translational allergy, 10:32, Clinical and Translational Allergy
- Publication Year :
- 2020
- Publisher :
- BioMed Central, 2020.
-
Abstract
- Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utility of measuring total IgE levels in the management of allergies, parasitosis, and immunodeficiencies, (b) factors that may influence serum IgE levels, (c) IgE as a marker of different disorders, and d) the relationship between ultra-low IgE levels and malignancy susceptibility. While elevated serum IgE is generally associated with allergic/atopic conditions, very low or absent IgE may hamper anti-tumour surveillance, indicating the importance of a balanced IgE-mediated immune function. Ultra-low IgE may prove to be an unexpected biomarker for cancer risk. Nevertheless, given the early stage of investigations conducted mostly in patients with diseases that influence IgE levels, in-depth mechanistic studies and stratification of malignancy risk based on associated demographic, immunological and clinical co-factors are warranted.
- Subjects :
- Pulmonary and Respiratory Medicine
Allergy
Immunology
Review
Immunoglobulin E
Malignancy
Atopy
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Immune system
IgE deficiency
Allergy diagnosis
medicine
Immunology and Allergy
Clinical significance
Cancer
Allergie
IgE
biology
business.industry
RC581-607
medicine.disease
030228 respiratory system
biology.protein
Biomarker (medicine)
Immunologic diseases. Allergy
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Clinical and Translational Allergy, Vol 10, Iss 1, Pp 1-16 (2020), Clinical and translational allergy, 10:32, Clinical and Translational Allergy
- Accession number :
- edsair.doi.dedup.....fd9d638e5cd5b96817974f895036ab06