Back to Search
Start Over
Association of cardiovascular disease risk factors with coronary artery calcium volume versus density
- Source :
- Heart (British Cardiac Society), vol 104, iss 2
- Publication Year :
- 2017
- Publisher :
- BMJ, 2017.
-
Abstract
- ObjectivesRecently, the density score of coronary artery calcium (CAC) has been shown to be associated with a lower risk of cardiovascular disease (CVD) events at any level of CAC volume. Whether risk factors for CAC volume and CAC density are similar or distinct is unknown. We sought to evaluate the associations of CVD risk factors with CAC volume and CAC density scores.MethodsBaseline measurements from 6814 participants free of clinical CVD were collected for the Multi-Ethnic Study of Atherosclerosis. Participants with detectable CAC (n=3398) were evaluated for this study. Multivariable linear regression models were used to evaluate independent associations of CVD risk factors with CAC volume and CAC density scores.ResultsWhereas most CVD risk factors were associated with higher CAC volume scores, many risk factors were associated with lower CAC density scores. For example, diabetes was associated with a higher natural logarithm (ln) transformed CAC volume score (standardised β=0.44 (95% CI 0.31 to 0.58) ln-units) but a lower CAC density score (β=−0.07 (−0.12 to −0.02) density units). Chinese, African-American and Hispanic race/ethnicity were each associated with lower ln CAC volume scores (β=−0.62 (−0.83to −0.41), −0.52 (−0.64 to −0.39) and −0.40 (−0.55 to −0.26) ln-units, respectively) and higher CAC density scores (β= 0.41 (0.34 to 0.47), 0.18 (0.12 to 0.23) and 0.21 (0.15 to 0.26) density units, respectively) relative to non-Hispanic White.ConclusionsIn a cohort free of clinical CVD, CVD risk factors are differentially associated with CAC volume and density scores, with many CVD risk factors inversely associated with the CAC density score after controlling for the CAC volume score. These findings suggest complex associations between CVD risk factors and these components of CAC.
- Subjects :
- Male
Aging
Cardiac Risk Factors And Prevention
Coronary Artery Disease
Cardiorespiratory Medicine and Haematology
030204 cardiovascular system & hematology
Cardiovascular
Cohort Studies
Coronary artery disease
0302 clinical medicine
Risk Factors
80 and over
Ethnicity
030212 general & internal medicine
Tomography
Aged, 80 and over
Middle Aged
Coronary Vessels
X-Ray Computed
Coronary artery calcium
Heart Disease
Cardiovascular Diseases
Cohort
Cardiology
Female
Cardiology and Cardiovascular Medicine
Cohort study
medicine.medical_specialty
Cardiac Computer Tomographic (ct) Imaging
Clinical Sciences
Lower risk
Article
03 medical and health sciences
Clinical Research
Diabetes mellitus
Internal medicine
medicine
Humans
cardiovascular diseases
Vascular Calcification
Heart Disease - Coronary Heart Disease
Aged
business.industry
Prevention
nutritional and metabolic diseases
Atherosclerosis
medicine.disease
United States
Surgery
Good Health and Well Being
Cardiovascular System & Hematology
Disease risk
Calcium
Tomography, X-Ray Computed
Densitometry
business
Subjects
Details
- ISSN :
- 1468201X and 13556037
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- Heart
- Accession number :
- edsair.doi.dedup.....fdceb20ea7b12d57e4c88544912148ff