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Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension
- Source :
- Journal Of Hypertension, Artículos CONICYT, CONICYT Chile, instacron:CONICYT, J Hypertens
- Publication Year :
- 2016
-
Abstract
- To identify novel biomarkers associated with pediatric primary hypertension.We recruited 350 participants (4-16 years). Anthropometric parameters and aldosterone, plasma renin activity, cortisol, cortisone, Homeostasis Model Assessment Insulin Resistance (HOMA-IR), high-sensitivity C-reactive protein, adiponectin, IL-6, plasminogen activator inhibitor type 1 levels and matrix metalloproteinase-9 and matrix metalloproteinase-2 (MMP-9 and MMP-2) activities were measured. Genomic DNA was isolated. Patients with altered glucose metabolism, severe obesity [BMI-SD score (BMI-SDS) 2.5], renovascular disease, primary aldosteronism and apparent mineralocorticoid excess syndrome were excluded.In selected participants (n = 320), SBP was positively correlated with BMI-SDS (r = 0.382, P 0.001), HOMA-IR (r = 0.211, P 0.001), MMP-9 activity (r = 0.215, P 0.001) and the cortisol/cortisone ratio (r = 0.231, P 0.001). DBP showed similar correlations with these variables. No correlation was observed with aldosterone or plasma renin activity. Participants were categorized as hypertensive (n = 59) or nonhypertensive (n = 261). In the univariate analysis, hypertensive patients had higher BMI-SDS (P 0.001), HOMA-IR (P 0.001), high-sensitivity C-reactive protein (P 0.001), MMP-9 activity (P 0.001), plasminogen activator inhibitor type 1 (P 0.001) and cortisol/cortisone ratio (P 0.001) than nonhypertensive patients. Multiple regression analysis showed that the variables that remained associated with hypertension were higher BMI-SDS [odds ratio (OR) = 3.74; 95% confidence interval (CI) = 1.84-7.58], a higher cortisol/cortisone ratio (OR = 3.92; 95% CI = 1.98-7.71) and increased MMP-9 activity (OR = 4.23; 95% CI = 2.15-8.32).We report that MMP-9 activity and the cortisol/cortisone ratio were higher in pediatric primary hypertensive patients, and these associations were independent of the effect of obesity. The potential role of these novel biomarkers in predicting hypertension risk and blood pressure regulation warrants further investigation.
- Subjects :
- 0301 basic medicine
Male
Hydrocortisone
Physiology
Blood Pressure
030204 cardiovascular system & hematology
Essential hypertension
Plasma renin activity
Body Mass Index
chemistry.chemical_compound
0302 clinical medicine
Diastole
Renin
Child
Aldosterone
Obesity, Morbid
C-Reactive Protein
Matrix Metalloproteinase 9
Child, Preschool
Hypertension
Matrix Metalloproteinase 2
Female
Adiponectin
Essential Hypertension
Cardiology and Cardiovascular Medicine
medicine.drug
medicine.medical_specialty
Adolescent
Systole
03 medical and health sciences
Insulin resistance
Internal medicine
Plasminogen Activator Inhibitor 1
Internal Medicine
medicine
Humans
business.industry
Interleukin-6
medicine.disease
Cortisone
030104 developmental biology
Blood pressure
Endocrinology
chemistry
Insulin Resistance
business
Homeostasis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal Of Hypertension, Artículos CONICYT, CONICYT Chile, instacron:CONICYT, J Hypertens
- Accession number :
- edsair.doi.dedup.....fdd0896cfd8278b89a66916b4cdd4714