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Nck Links Nephrin to Actin in Kidney Podocytes
- Source :
- Cell. 125(2):221-224
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Two papers, one in Nature (Jones et al., 2006) and the other in the Journal of Clinical Investigation (Verma et al., 2006) show that Nck adaptor proteins connect phosphorylated nephrin with actin polymerization in podocyte foot processes, structures important for slit-diaphragm formation in the kidney. Their results further our understanding of podocyte development and repair in glomerular disease.
- Subjects :
- medicine.medical_specialty
Kidney Glomerulus
Podocyte foot
macromolecular substances
General Biochemistry, Genetics and Molecular Biology
Podocyte
Nephrin
Mice
Internal medicine
Clinical investigation
medicine
Animals
Actin
Cells, Cultured
Cytoskeleton
Adaptor Proteins, Signal Transducing
Oncogene Proteins
Kidney
biology
urogenital system
Podocytes
Biochemistry, Genetics and Molecular Biology(all)
Signal transducing adaptor protein
Membrane Proteins
Actins
Cell biology
medicine.anatomical_structure
Endocrinology
biology.protein
Phosphorylation
Subjects
Details
- ISSN :
- 00928674
- Volume :
- 125
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....fdf07979b4c9c5eb7ef5f7c89f5a86b3
- Full Text :
- https://doi.org/10.1016/j.cell.2006.04.002