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Increased Levels of Plasma Soluble Sema4D in Patients with Heart Failure
- Source :
- PLoS ONE, PLoS ONE, Vol 8, Iss 5, p e64265 (2013)
- Publication Year :
- 2013
-
Abstract
- Semaphorin 4D (Sema4D/CD100) is a 150-kDa transmembrane glycoprotein expressed by platelets and T-cells. When these cells are activated, Sema4D is cleaved proteolytically, generating a biologically active 120-kDa fragment (soluble Sema4D) capable of targeting receptors on platelets, B-cells, endothelial cells and tumor cells. However, its plasma levels and significance in heart failure (HF) have not been reported. In this study, we established an ELISA and detected soluble Sema4D in human plasma. In healthy controls, plasma Sema4D levels were higher in men than women (5.15±3.30 ng/mL, n = 63, vs. 4.19±2.39 ng/mL, n = 63, P
- Subjects :
- Male
CD3 Complex
Glycobiology
lcsh:Medicine
Gene Expression
Semaphorins
CD8-Positive T-Lymphocytes
Cardiovascular
Biochemistry
Endocrinology
Blood plasma
Molecular Cell Biology
Platelet
Receptor
lcsh:Science
education.field_of_study
B-Lymphocytes
Multidisciplinary
T Cells
Hematology
Middle Aged
CD4 Antigens
Medicine
Female
Research Article
Platelets
Adult
medicine.medical_specialty
Immune Cells
Population
Diabetes Complications
Sex Factors
Antigens, CD
Diabetes mellitus
Internal medicine
medicine
Diabetes Mellitus
Animals
Humans
Platelet activation
Lymphocyte Count
education
Biology
Glycoproteins
Diabetic Endocrinology
Heart Failure
Plasma Proteins
business.industry
lcsh:R
Proteins
Correction
Diabetes Mellitus Type 1
Diabetes Mellitus Type 2
medicine.disease
Heart failure
Case-Control Studies
Immunologic Techniques
Clinical Immunology
lcsh:Q
business
CD8
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 8
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....fe03a3b12b2c10aae34e2a1249f4ba03