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Synthesis, Characterization, In-Vitro and In-Vivo Evaluation of Ketorolac Tromethamine-Loaded Hydrogels of Glutamic Acid as Controlled Release Carrier
- Source :
- Polymers, Polymers, Vol 13, Iss 3541, p 3541 (2021), Volume 13, Issue 20
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Glutamic acid-co-poly(acrylic acid) (GAcPAAc) hydrogels were prepared by the free radical polymerization technique using glutamic acid (GA) as a polymer, acrylic acid (AAc) as a monomer, ethylene glycol dimethylacrylate (EGDMA) as a cross-linker, and ammonium persulfate (APS) as an initiator. Increase in gel fraction was observed with the increasing concentration of glutamic acid, acrylic acid, and ethylene glycol dimethylacrylate. High percent porosity was indicated by developed hydrogels with the increase in the concentration of glutamic acid and acrylic acid, while a decrease was seen with the increasing concentration of EGDMA, respectively. Maximum swelling and drug release was exhibited at high pH 7.4 compared to low pH 1.2 by the newly synthesized hydrogels. Similarly, both swelling and drug release increased with the increasing concentration of glutamic acid and acrylic acid and decreased with the increase in ethylene glycol dimethylacrylate concentration. The drug release was considered as non-Fickian transport and partially controlled by viscoelastic relaxation of hydrogel. In-vivo study revealed that the AUC0–∞ of fabricated hydrogels significantly increased compared to the drug solution and commercial product Keten. Hence, the results indicated that the developed hydrogels could be used as a suitable carrier for controlled drug delivery.
- Subjects :
- in-vivo study
Polymers and Plastics
Chemistry
Radical polymerization
technology, industry, and agriculture
Organic chemistry
General Chemistry
Glutamic acid
Controlled release
Article
swelling study
chemistry.chemical_compound
QD241-441
Drug delivery
Self-healing hydrogels
Ammonium persulfate
Ethylene glycol
hydrogels
drug release
Nuclear chemistry
Acrylic acid
Subjects
Details
- ISSN :
- 20734360
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Polymers
- Accession number :
- edsair.doi.dedup.....fe1b12bff3a53cef70403f3d1836620e