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Parallels between DNA and collagen – comparing elastic models of the double and triple helix
- Source :
- Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017), Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Multi-stranded helices are widespread in nature. The interplay of polymeric properties with biological function is seldom discussed. This study probes analogies between structural and mechanical properties of collagen and DNA. We modeled collagen with Eulerian rotational and translational parameters of adjacent rungs in the triple-helix ladder and developed statistical potentials by extracting the dispersion of the parameters from a database of atomic-resolution structures. The resulting elastic model provides a common quantitative way to describe collagen deformations upon interacting with integrins or matrix metalloproteinase and DNA deformations upon protein binding. On a larger scale, deformations in Type I collagen vary with a periodicity consistent with the D-periodic banding of higher-order fibers assemblies. This indicates that morphologies of natural higher-order collagen packing might be rooted in the characteristic deformation patterns.
- Subjects :
- Models, Molecular
0301 basic medicine
Integrins
Materials science
Integrin
lcsh:Medicine
Ligands
Article
Protein Structure, Secondary
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Protein structure
Amino Acid Sequence
Elasticity (economics)
lcsh:Science
Quantitative Biology::Biomolecules
Multidisciplinary
biology
Extramural
lcsh:R
DNA
Elasticity
030104 developmental biology
chemistry
biology.protein
Biophysics
Nucleic Acid Conformation
Thermodynamics
lcsh:Q
Collagen
Matrix Metalloproteinase 1
030217 neurology & neurosurgery
Type I collagen
Protein Binding
Triple helix
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....fe30678b9c7eb7f60be2bf08c0a8874f