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Present Status and Future Trends of Natural-Derived Compounds Targeting T Helper (Th) 17 and Microsomal Prostaglandin E Synthase-1 (mPGES-1) as Alternative Therapies for Autoimmune and Inflammatory-Based Diseases

Authors :
Alessia Pernice
Anella Saviano
Carmen Foreste
Federica Raucci
Francesco Maione
Nicola Mascolo
Chiara Indolfi
Gian Marco Casillo
Asif J. Iqbal
Saviano, A.
Raucci, F.
Casillo, G. M.
Indolfi, C.
Pernice, A.
Foreste, C.
Iqbal, A. J.
Mascolo, N.
Maione, F.
Source :
Molecules, Vol 25, Iss 6016, p 6016 (2020), Molecules
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

Several natural-based compounds and products are reported to possess anti-inflammatory and immunomodulatory activity both in vitro and in vivo. The primary target for these activities is the inhibition of eicosanoid-generating enzymes, including phospholipase A2, cyclooxygenases (COXs), and lipoxygenases, leading to reduced prostanoids and leukotrienes. Other mechanisms include modulation of protein kinases and activation of transcriptases. However, only a limited number of studies and reviews highlight the potential modulation of the coupling enzymatic pathway COX-2/mPGES-1 and Th17/Treg circulating cells. Here, we provide a brief overview of natural products/compounds, currently included in the Italian list of botanicals and the BELFRIT, in different fields of interest such as inflammation and immunity. In this context, we focus our opinion on novel therapeutic targets such as COX-2/mPGES-1 coupling enzymes and Th17/Treg circulating repertoire. This paper is dedicated to the scientific career of Professor Nicola Mascolo for his profound dedication to the study of natural compounds.

Details

Language :
English
ISSN :
14203049
Volume :
25
Issue :
6016
Database :
OpenAIRE
Journal :
Molecules
Accession number :
edsair.doi.dedup.....fe31b94e9d43e23fd083af86bdb91d2c