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Adult T-cell Lymphoma/Leukemia With Angioimmunoblastic T-cell Lymphomalike Features: Report of 11 Cases
- Source :
- The American Journal of Surgical Pathology. 31:216-223
- Publication Year :
- 2007
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2007.
-
Abstract
- In adult T-cell lymphoma/leukemia (ATLL), the neoplastic lymphoid cells are usually medium-sized to large, often with pronounced nuclear pleomorphism compatible with the diagnosis of diffuse pleomorphic peripheral T-cell lymphoma. We describe here 11 patients with the rare morphologic variant of ATLL, angioimmunoblastic T-cell lymphoma (AILT)-like type. The examined lymph nodes showed proliferation of high endothelial venules and presence of various infiltrating inflammatory cells including plasma cells and eosinophils. The lymphoma cells were medium-to-large size with clear cytoplasm. These findings were suggestive of AILT. However, immunohistochemical features of AILT, namely, CD10 and CXCL13 expression in lymphoma cells and proliferation of CD21-positive follicular dendritic cells, were not detected. Two cases were CXCR3-positive, whereas 9 expressed CCR4, which are usually positive in ATLL. All patients were positive for antiadult T-cell leukemia/lymphoma-associated antigen, which is a specific antibody for human T-cell lymphotropic virus type-I. Southern blot analysis revealed proviral DNA integration in lymphoma cells in 9 patients. The latter was not evident in the first biopsy of 2 patients but in the second biopsy obtained within several months after the first biopsy revealed definite proviral integration. Almost all patients showed aggressive clinical course and poor survival (median survival: 5 mo). This is the first report of ATLL with AILT-like morphologic features.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Angioimmunoblastic T-cell lymphoma
T cell
High endothelial venules
Lymphoma, T-Cell
Adult T-cell leukemia/lymphoma
Pathology and Forensic Medicine
Antigens, CD
immune system diseases
hemic and lymphatic diseases
Biopsy
Biomarkers, Tumor
Humans
Leukemia-Lymphoma, Adult T-Cell
Medicine
Aged
medicine.diagnostic_test
Follicular dendritic cells
business.industry
Middle Aged
medicine.disease
HTLV-I Infections
Lymphoma
Survival Rate
Leukemia
medicine.anatomical_structure
Immunoblastic Lymphadenopathy
DNA, Viral
Female
Surgery
Anatomy
business
Subjects
Details
- ISSN :
- 01475185
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- The American Journal of Surgical Pathology
- Accession number :
- edsair.doi.dedup.....fe4d771831fd80c0e972699ee7aa1efc