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Chronic unpredictable mild stress combined with a high-fat diets aggravates atherosclerosis in rats
- Source :
- Lipids in Health and Disease
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Background Depression and high-fat diet are both known as independent risk factors for atherosclerosis and other cardiovascular diseases, suggesting the interaction of psychological and physiological factors in the development of these diseases. The liver is a crucial organ that facilitate lipid metabolism especially in reverse cholesterol transport (RCT), while according to the theory of Traditional Chinese Medicine, depression as a kind of psychological stress has an influence on hepatic function. So there seem to be some links between depression and lipid metabolic disorders. Methods To investigate these links, we separately treated rats with chronic unpredictable mild stress (CMS) and/or a high-fat diet (HD) to evaluate the development of atherosclerosis and the expression of hepatic ABCG8, ABCG5, SR-BI, CYP7A1, LXRα, and LCAT which were associated with reverse cholesterol transport. Results This study provided evidence that high-fat diet greatly decreased these genes expression related to RCT while chronic stress alone tended to promote RCT. Chronic unpredictable mild stress combined with a high-fat diet attenuated RCT and aggravated atherogenesis. Conclusions These observations suggested that chronic psychological stress alone is virtually propitious to lipid metabolism, however when under a condition of high-fat diet, it deteriorated atherosclerotic plague and did harm to RCT.
- Subjects :
- Chronic unpredictable mild stress
Male
medicine.medical_specialty
Clinical chemistry
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Clinical nutrition
Biology
Diet, High-Fat
Cholesterol 7 alpha-hydroxylase
Rats, Sprague-Dawley
chemistry.chemical_compound
Endocrinology
Stress, Physiological
Internal medicine
medicine
Animals
Chronic stress
Biochemistry, medical
Cholesterol
Research
Biochemistry (medical)
Reverse cholesterol transport
Biological Transport
Lipid metabolism
Atherosclerosis
Rats
High-fat diet
chemistry
Lipidology
Subjects
Details
- ISSN :
- 1476511X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Lipids in Health and Disease
- Accession number :
- edsair.doi.dedup.....fe519efa193431cbddd4c177bb113339