Back to Search
Start Over
Spinal cord atrophy in multiple sclerosis caused by white matter volume loss
- Publication Year :
- 2016
-
Abstract
- Objective To assess the relative contributions of white matter (WM) and gray matter (GM) volume loss to spinal cord atrophy in multiple sclerosis (MS). Design Postmortem study of transverse sections obtained from 5 levels of the spinal cord, with measurement of the cross-sectional GM and WM areas. Setting Department of Neuropathology, University of Nottingham, Nottingham, England. Patients Fifty-five MS cases and 33 controls. Main Outcome Measures Size of the WM and GM areas. Results The WM area was significantly reduced in MS cases in the upper but not the lower cord levels. The GM area was not significantly different between MS and control cases. Conclusion Spinal cord atrophy in MS is due to WM rather than GM volume loss.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Silver Staining
Cord
Multiple Sclerosis
Central nervous system
Neuropathology
Nerve Fibers, Myelinated
Spinal Cord Diseases
Central nervous system disease
White matter
Atrophy
Sex Factors
Arts and Humanities (miscellaneous)
Neural Pathways
Medicine
Humans
Aged
Aged, 80 and over
Neurons
business.industry
Multiple sclerosis
Age Factors
Reproducibility of Results
Middle Aged
medicine.disease
Spinal cord
medicine.anatomical_structure
Spinal Cord
Female
Neurology (clinical)
Autopsy
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....fe5a7492fe4493cf543a13b348845174