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Aminoterminal Propeptide of Type III Procollagen: A Marker of Disease Activity in Schistosomal Patients
- Publication Year :
- 1991
- Publisher :
- Kooperation de Gruyter, 1991.
-
Abstract
- The serum concentration of aminoterminal propeptide of type III procollagen was measured in 44 Egyptian healthy controls and 29 patients with hepatosplenomegaly originating from endemic areas for schistosomiasis in Egypt. Patients were classified into two main groups according to the histopathological pattern of the liver biopsy: patients with active schistosomal liver fibrosis and patients with inactive schistosomal liver fibrosis. Serum aminoterminal propeptide of type III procollagen levels were elevated in most of patients with active fibrosis but not in those with inactive schistosomiasis. From the present work, it is suggested that aminoterminal propeptide of type III procollagen can be used as a marker for active fibrogenesis in patients with schistosomal liver fibrosis.
- Subjects :
- Adult
Liver Cirrhosis
Male
Pathology
medicine.medical_specialty
Adolescent
Liver Diseases, Parasitic
Clinical Biochemistry
education
Radioimmunoassay
Hepatosplenomegaly
Helminthiasis
Schistosomiasis
Biology
Fibrosis
medicine
Animals
Humans
Protein precursor
medicine.diagnostic_test
Biochemistry (medical)
General Medicine
Middle Aged
medicine.disease
Peptide Fragments
Schistosomiasis mansoni
Type III Procollagen
Liver biopsy
Female
medicine.symptom
Procollagen
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....fe5da7d4eda80f81b37f56ff41c89175