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Dengue Virus Infection Activates Interleukin-1β to Induce Tissue Injury and Vascular Leakage
- Source :
- Frontiers in Microbiology, Frontiers in Microbiology, Vol 10 (2019)
- Publication Year :
- 2019
- Publisher :
- Frontiers Media SA, 2019.
-
Abstract
- Dengue virus (DENV) infection causes several diseases ranging from dengue fever to life-threatening dengue hemorrhagic fever and dengue shock syndrome characterized by endothelial dysfunction, vascular leakage, and shock. Here, we identify a potential mechanism by which DENV induces tissue injury and vascular leakage by promoting the activation of interleukin (IL)-1β. DENV facilitates IL-1β secretion in infected patients, mice, human peripheral blood mononuclear cells (PBMCs), mouse bone marrow-derived macrophages (BMDMs), and monocyte-differentiated macrophages (THP-1) via activating the NLRP3 inflammasome. The accumulated data suggest that IL-1β probably induces vascular leakage and tissue injury in interferon-alpha/beta receptor 1 deficient C57BL/6 mice (IFNAR -/- C57BL/6), whereas IL-1 receptor antagonist (IL-1RA) alleviates these effects of IL-1β. Finally, administration of recombinant IL-1β protein results in vascular leakage and tissue injury in C57BL/6 mice. Together, the accumulated results demonstrate that IL-1β contributes to DENV-associated pathology and suggest that IL-1RA acts as a potential agent for the treatment of DENV-associated diseases.
- Subjects :
- Microbiology (medical)
lcsh:QR1-502
Dengue virus
medicine.disease_cause
vascular leakage
Microbiology
Peripheral blood mononuclear cell
lcsh:Microbiology
Dengue fever
03 medical and health sciences
IL-1RA
Interferon
medicine
Endothelial dysfunction
Original Research
030304 developmental biology
0303 health sciences
dengue virus
030306 microbiology
business.industry
Interleukin
Inflammasome
inflammatory response
medicine.disease
NLRP3 inflammasome
Interleukin 1 receptor antagonist
IL-1β
Immunology
business
medicine.drug
Subjects
Details
- ISSN :
- 1664302X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Microbiology
- Accession number :
- edsair.doi.dedup.....fe5ff06fdc7065296325c6cf3f14e866
- Full Text :
- https://doi.org/10.3389/fmicb.2019.02637