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Cancer Prevention with Promising Natural Products: Mechanisms of Action and Molecular Targets
- Source :
- Anti-Cancer Agents in Medicinal Chemistry. 12:1159-1184
- Publication Year :
- 2012
- Publisher :
- Bentham Science Publishers Ltd., 2012.
-
Abstract
- Cancer is the second leading cause of death worldwide. There is greater need for more effective and less toxic therapeutic and preventive strategies. Natural products are becoming an important research area for novel and bioactive molecules for drug discovery. Phytochemicals and dietary compounds have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Many active phytochemicals are in human clinical trials. Studies have indicated that daily consumption of dietary phytochemicals have cancer protective effects against carcinogens. They can inhibit, delay, or reverse carcinogenesis by inducing detoxifying and antioxidant enzymes systems, regulating inflammatory and proliferative signaling pathways, and inducing cell cycle arrest and apoptosis. Epidemiological studies have also revealed that high dietary intakes of fruits and vegetables reduce the risk of cancer. This review discusses potential natural cancer preventive compounds, their molecular targets, and their mechanisms of actions.
- Subjects :
- Cancer Research
Antioxidant
medicine.medical_treatment
Apoptosis
Biology
Pharmacology
medicine.disease_cause
Chemoprevention
Article
Neoplasms
Drug Discovery
medicine
Animals
Anticarcinogenic Agents
Humans
Carcinogen
Biological Products
Cancer prevention
Neovascularization, Pathologic
Drug discovery
Cancer
medicine.disease
Clinical trial
Molecular Medicine
Signal transduction
Carcinogenesis
Subjects
Details
- ISSN :
- 18715206
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Anti-Cancer Agents in Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....fe7ea97bb0cf7e4a937f40409efd440f