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Captopril in the hepatorenal syndrome
- Source :
- Europe PubMed Central
- Publication Year :
- 1985
-
Abstract
- Five patients with hepatorenal syndrome were treated with the orally active angiotensin-converting enzyme inhibitor captopril (25 or 50 mg 6 hourly) for up to 48 hours. Only one patient showed a significant increase in urinary sodium concentration (from less than 10 to 70 mmol/liter), but without associated diuresis; renal function continued to deteriorate in all patients with persistent oliguria and rising serum creatinine. The outcome was uniformly fatal. These results suggest that in the hepatorenal syndrome, captopril in standard dosage is without benefit, and provide further evidence that the changes in the renin-angiotensin system are probably secondary to reduced renal perfusion from some other cause.
- Subjects :
- Adult
Male
medicine.medical_specialty
Captopril
Urology
Radioimmunoassay
Renal function
Diuresis
Angiotensin-Converting Enzyme Inhibitors
Blood Pressure
Iodine Radioisotopes
chemistry.chemical_compound
Hepatorenal syndrome
Oliguria
Internal medicine
Renin
Medicine
Humans
Aldosterone
Creatinine
business.industry
Angiotensin II
Liver Diseases
Hepatobiliary disease
Sodium
Gastroenterology
Syndrome
Middle Aged
medicine.disease
Endocrinology
chemistry
Cardiovascular agent
Female
Kidney Diseases
medicine.symptom
Angiotensin I
business
medicine.drug
Subjects
Details
- ISSN :
- 01920790
- Volume :
- 7
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of clinical gastroenterology
- Accession number :
- edsair.doi.dedup.....fe80a4491c059a88de95eeaf9f922dc9