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Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus
- Source :
- Molecules, Molecules, Vol 23, Iss 11, p 2899 (2018)
- Publication Year :
- 2018
-
Abstract
- Sacred lotus (Nelumbo nucifera Gaertn.) is an ancient aquatic plant used throughout Asia for its nutritional and medicinal properties. Benzylisoquinoline alkaloids (BIAs), mostly within the aporphine and bisbenzylisoquinoline structural categories, are among the main bioactive constituents in the plant. The alkaloids of sacred lotus exhibit promising anti-cancer, anti-arrhythmic, anti-HIV, and anti-malarial properties. Despite their pharmacological significance, BIA metabolism in this non-model plant has not been extensively investigated. In this review, we examine the diversity of BIAs in sacred lotus, with an emphasis on the distinctive stereochemistry of alkaloids found in this species. Additionally, we discuss our current understanding of the biosynthetic genes and enzymes involved in the formation of 1-benzylisoquinoline, aporphine, and bisbenzylisoquinoline alkaloids in the plant. We conclude that a comprehensive functional characterization of alkaloid biosynthetic enzymes using both in vitro and in vivo methods is required to advance our limited knowledge of BIA metabolism in the sacred lotus.
- Subjects :
- 0106 biological sciences
0301 basic medicine
cytochrome P450 monooxygenase
Lotus
Nelumbo nucifera
Pharmaceutical Science
Review
Biology
Nelumbo
norcoclaurine synthase
01 natural sciences
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
chemistry.chemical_compound
Alkaloids
lcsh:Organic chemistry
Biosynthesis
Drug Discovery
Botany
heterocyclic compounds
Aporphine
sacred lotus
Physical and Theoretical Chemistry
Benzylisoquinoline
Alkaloid
Organic Chemistry
fungi
stereochemistry
food and beverages
Stereoisomerism
Methyltransferases
15. Life on land
biology.organism_classification
benzylisoquinoline alkaloids
Biosynthetic enzyme
030104 developmental biology
medicinal properties
chemistry
Chemistry (miscellaneous)
Molecular Medicine
methyltransferase
Genome, Plant
010606 plant biology & botany
Biosynthetic genes
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 23
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....fea7e49cfacbb621c070137e7339ff14