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Prognostic values of soluble CD30 and CD30 gene polymorphisms in heart transplantation
- Source :
- Transplantation. 81(8)
- Publication Year :
- 2006
-
Abstract
- Pretransplant soluble CD30 (sCD30) is a predictor of kidney graft outcome. Its status as a predictor of heart transplant (HT) outcome has not been established. We have studied this question by assessing sCD30 levels and the number of (CCAT) n repeats of the microsatellite in the CD30 promoter region, which is able alone to repress gene transcription, in the sera of 83 HT patients and 77 of their donors. sCD30 was non-significantly increased in the patients, whereas there were no differences in the CD30 microsatellite allele frequencies. A negative correlation between the number of (CCAT) n and sCD30 levels was evident in the donors. Patients with pretransplant sCD30≤30 U/ml displayed a significantly better survival. In conclusion, sCD30 levels are predictive of HT outcome.
- Subjects :
- Adult
Male
medicine.medical_specialty
CD30
Adolescent
medicine.medical_treatment
Ki-1 Antigen
Gastroenterology
hemic and lymphatic diseases
Internal medicine
Genotype
medicine
Humans
genetics
Allele frequency
Gene
Aged
Heart transplantation
Transplantation
Kidney
Polymorphism, Genetic
heart transplantation
business.industry
Promoter
Middle Aged
Prognosis
medicine.anatomical_structure
Immunology
Heart Transplantation
Female
business
Microsatellite Repeats
Subjects
Details
- ISSN :
- 00411337
- Volume :
- 81
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Transplantation
- Accession number :
- edsair.doi.dedup.....feaa070fbd89b14c0fcd71f66df8ec80