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Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: A meta-analysis
- Publication Year :
- 2010
- Publisher :
- Baishideng Publishing Group Co., Limited, 2010.
-
Abstract
- To find evidences about whether NOD1/CARD4 insertion/deletion polymorphism is associated with inflammatory bowel disease by meta-analysis.We surveyed the studies on the association of NOD1/CARD4 insertion/deletion polymorphism with inflammatory bowel disease in PubMed. Meta-analysis was performed for genotypes GG/T vs T/T, GG/GG vs T/T, GG/T + GG/GG vs T/T, GG/GG vs T/T + GG/T, and GG allele vs T allele in a fixed/random effect model.We identified 8 studies (6439 cases and 4798 controls) in Caucasian populations using PubMed search. We found no association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease, Crohn's disease, and ulcerative colitis. Stratification of cases by age showed that NOD1/CARD4 insertion/deletion polymorphism was associated with inflammatory bowel disease in younger age group at onset (40 years) (GG vs T: OR = 0.68, 95% CI: 0.50-0.93, P = 0.02; GG/T + GG/GG vs T/T: OR = 0.71, 95% CI: 0.59-0.85, P = 0.0003).This meta-analysis demonstrates an association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease in the younger age group at onset (40 years) in Caucasian populations.
- Subjects :
- Brief Article
Single-nucleotide polymorphism
digestive system
Nod1 Signaling Adaptor Protein
Genotype
Genetic variation
NOD1
Medicine
Humans
Genetic Predisposition to Disease
Allele
Gene
Genetics
Polymorphism, Genetic
business.industry
Haplotype
Gastroenterology
General Medicine
Inflammatory Bowel Diseases
digestive system diseases
body regions
Mutagenesis, Insertional
Meta-analysis
Immunology
business
Gene Deletion
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....feaa5d9a8368ac0721dc7c822a20f73a