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Serum Metabolite Biomarkers for Predicting Residual Feed Intake (RFI) of Young Angus Bulls
- Source :
- Metabolites, Volume 10, Issue 12, Metabolites, Vol 10, Iss 491, p 491 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Residual feed intake (RFI) is a feed efficiency measure commonly used in the livestock industry to identify animals that efficiently/inefficiently convert feed into meat or body mass. Selection for low-residual feed intake (LRFI), or feed efficient animals, is gaining popularity among beef producers due to the fact that LRFI cattle eat less and produce less methane per unit weight gain. RFI is a difficult and time-consuming measure to perform, and therefore a simple blood test that could distinguish high-RFI (HRFI) from LRFI animals (early on) would potentially benefit beef farmers in terms of optimizing production or selecting which animals to cull or breed. Using three different metabolomics platforms (nuclear magnetic resonance (NMR) spectrometry, liquid chromatography-tandem mass spectrometry (LC-MS/MS), and inductively coupled plasma mass spectrometry (ICP-MS)) we successfully identified serum biomarkers for RFI that could potentially be translated to an RFI blood test. One set of predictive RFI biomarkers included formate and leucine (best for NMR), and another set included C4 (butyrylcarnitine) and LysoPC(28:0) (best for LC-MS/MS). These serum biomarkers have high sensitivity and specificity (AUROC &gt<br />0.85), for distinguishing HRFI from LRFI animals. These results suggest that serum metabolites could be used to inexpensively predict and categorize bovine RFI values. Further validation using a larger, more diverse cohort of cattle is required to confirm these findings.
- Subjects :
- 0301 basic medicine
Endocrinology, Diabetes and Metabolism
Metabolite
metabolite
lcsh:QR1-502
Biology
Biochemistry
Feed conversion ratio
lcsh:Microbiology
Article
03 medical and health sciences
chemistry.chemical_compound
Animal science
Metabolomics
medicine
Blood test
Molecular Biology
Inductively coupled plasma mass spectrometry
medicine.diagnostic_test
Angus bulls
0402 animal and dairy science
04 agricultural and veterinary sciences
040201 dairy & animal science
Breed
030104 developmental biology
chemistry
residual feed intake
biomarker
Residual feed intake
medicine.symptom
Weight gain
serum
Subjects
Details
- Language :
- English
- ISSN :
- 22181989
- Database :
- OpenAIRE
- Journal :
- Metabolites
- Accession number :
- edsair.doi.dedup.....fef76582459646e36f91954523b36484
- Full Text :
- https://doi.org/10.3390/metabo10120491