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An Example of Personalized Treatment in HR+ HER2+ Long Survivor Breast Cancer Patient (Case Report)
An Example of Personalized Treatment in HR+ HER2+ Long Survivor Breast Cancer Patient (Case Report)
- Source :
- Current Oncology, Vol 28, Iss 184, Pp 1980-1987 (2021), Current Oncology
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Background. Personalized therapy is becoming increasingly popular in oncological scenarios, not only based on molecular pharmacological targets, but also preventing any drug–drug–gene interaction (DDGI), which could lead to severe toxicities. Single nucleotide polymorphisms (SNPs), the individual germline sequence variations in genes involved in drug metabolism, are correlated to interindividual response to drugs and explain both efficacy and toxicity profiles reported by patients. Case presentation. We present the case of a woman suffering from triple-positive breast cancer; she had early-stage disease at the onset and after four years developed metastatic disease. During her history, she presented different toxicities due to antineoplastic treatments. Particularly, hypertransaminasemia was found during every line of treatment. Nevertheless, we were able to guarantee the patient an excellent therapeutic adhesion thanks to the supportive treatments and the reduction of drug dosage. Moreover, we conducted a simultaneous analysis of the patient’s biochemical and genomic data thanks to Drug-PIN software, and we found several significant SNPs of the main enzymes and transporters involved in drug metabolism. Conclusion. Our case report demonstrated the relevance of DDGI in clinical practice management of a patient treated for advanced breast cancer, suggesting the role of Drug-PIN software as an easy-to-use tool to prevent adverse events during cancer treatment and to help physicians in therapeutic algorithms. However, further studies are needed to confirm these results.
- Subjects :
- 0301 basic medicine
Oncology
Drug
medicine.medical_specialty
media_common.quotation_subject
Personalized treatment
Single-nucleotide polymorphism
Case Report
hormone receptor positive (HR+)
Disease
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
medicine
Adverse effect
RC254-282
media_common
business.industry
Cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
HER2+ breast cancer
single nucleotide polymorphisms (SNPs)
medicine.disease
drug-drug-gene interaction (DDGI)
030104 developmental biology
030220 oncology & carcinogenesis
business
Drug metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 11980052 and 17187729
- Volume :
- 28
- Issue :
- 184
- Database :
- OpenAIRE
- Journal :
- Current Oncology
- Accession number :
- edsair.doi.dedup.....ff244c7d550f4a021a4edb509a08ce72