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Effects of Fermented Milk Containing Lacticaseibacillus paracasei Strain Shirota on Constipation in Patients with Depression: A Randomized, Double-Blind, Placebo-Controlled Trial
- Source :
- Nutrients, Volume 13, Issue 7, Nutrients, Vol 13, Iss 2238, p 2238 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Probiotics have been shown to benefit patients with constipation and depression, but whether they specifically alleviate constipation in patients with depression remains unclear. The aim of this study was to investigate the effect of Lacticaseibacillus paracasei strain Shirota (LcS), formerly Lactobacillus casei strain Shirota, on constipation in patients with depression with specific etiology and gut microbiota and on depressive regimens. Eighty-two patients with constipation were recruited. The subjects consumed 100 mL of a LcS beverage (108 CFU/mL) or placebo every day for 9 weeks. After ingesting beverages for this period, we observed no significant differences in the total patient constipation-symptom (PAC-SYM) scores in the LcS group when compared with the placebo group. However, symptoms/scores in item 7 (rectal tearing or bleeding after a bowel movement) and items 8–12 (stool symptom subscale) were more alleviated in the LcS group than in the placebo group. The Beck Depression Index (BDI) and Hamilton Depression Rating Scale (HAMD) scores were all significantly decreased, and the degree of depression was significantly improved in both the placebo and LcS groups (p &lt<br />0.05), but there was no significant difference between the groups. The LcS intervention increased the beneficial Adlercreutzia, Megasphaera and Veillonella levels and decreased the bacterial levels related to mental illness, such as Rikenellaceae_RC9_gut_group, Sutterella and Oscillibacter. Additionally, the interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) levels were significantly decreased in both the placebo and LcS groups (p &lt<br />0.05). In particular, the IL-6 levels were significantly lower in the LcS group than the placebo group after the ingestion period (p &lt<br />0.05). In conclusion, the daily consumption of LcS for 9 weeks appeared to relieve constipation and improve the potentially depressive symptoms in patients with depression and significantly decrease the IL-6 levels. In addition, the LcS supplementation also appeared to regulate the intestinal microbiota related to mental illness.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Constipation
Cultured Milk Products
Lacticaseibacillus paracasei strain Shirota (LcS)
Placebo-controlled study
Gut flora
Placebo
Gastroenterology
Article
03 medical and health sciences
Feces
0302 clinical medicine
Double-Blind Method
Internal medicine
Hamd
Medicine
Ingestion
Animals
Humans
TX341-641
Depression (differential diagnoses)
Nutrition and Dietetics
biology
integumentary system
business.industry
Nutrition. Foods and food supply
Depression
Probiotics
constipation
Lacticaseibacillus paracasei
Middle Aged
biology.organism_classification
Gastrointestinal Microbiome
030104 developmental biology
Treatment Outcome
Defecation
030211 gastroenterology & hepatology
Female
medicine.symptom
business
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....ff29918c5ae93655de363011aee20025