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Modification of bronchial hyperreactivity after treatment with sodium cromoglycate during pollen season
- Source :
- Journal of Allergy and Clinical Immunology. 75:460-467
- Publication Year :
- 1985
- Publisher :
- Elsevier BV, 1985.
-
Abstract
- Repeated bronchial histamine challenges before, during, and after the birch pollen season were performed in 22 allergic patients with bronchial hyperreactivity (BHR) treated for 6 wk with sodium cromoglycate (SCG), 20 mg, four times a day, or placebo in a double-blind, randomized group comparison. Clinical assessments of the asthmatic symptom score and peak expiratory flow revealed less symptoms and less use of bronchodilators in the SCG group. Responsiveness to histamine was significantly increased in the placebo group after 14 days with high pollen counts. After the season there was an immediate return to preseasonal value. There was no change in responsiveness in the SCG group, demonstrating significant protection against pollen-induced increase of BHR. The results support the hypothesis that inhibition of mediator release, which is demonstrated for SCG, leads to a reduction of the nonspecific BHR.
- Subjects :
- Adult
Male
medicine.medical_specialty
Allergy
Adolescent
medicine.medical_treatment
Immunology
Bronchi
medicine.disease_cause
Placebo
Bronchial Provocation Tests
law.invention
chemistry.chemical_compound
Randomized controlled trial
law
Forced Expiratory Volume
Internal medicine
Pollen
Cromolyn Sodium
medicine
Humans
Immunology and Allergy
Bronchus
Chemotherapy
business.industry
Middle Aged
medicine.disease
Asthma
medicine.anatomical_structure
Endocrinology
chemistry
Anesthesia
Sodium cromoglycate
Female
Seasons
business
Histamine
Subjects
Details
- ISSN :
- 00916749
- Volume :
- 75
- Database :
- OpenAIRE
- Journal :
- Journal of Allergy and Clinical Immunology
- Accession number :
- edsair.doi.dedup.....ff30303f1783b817cb7748755eea4c3f