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Tools in the Design of Therapeutic Drugs for CNS Disorders: An up-to-date Review
- Source :
- Current molecular pharmacology. 11(4)
- Publication Year :
- 2018
-
Abstract
- Background The brain is a vital part of the central nervous system (CNS), characterized by the presence of soft tissue in its internal structure which protects itself. Research on design of drugs for CNS disorders is in progress and up to date information is required for further investigation. Objective The present paper is written with the objective to compile all the available data and information on CNS disorders and CNS acting drugs. CNS acting drugs are important to consider because some drugs get ineffective owing to incapability to efficiently deliver and sustain them within the brain for effective treatment. Cns disorders The current trend to design therapeutic drugs for CNS disorders focuses on neurotransmitters release and their reuptake, including Parkinson's, Alzheimer's, and other CNS disorders. The disorders associated with CNS are characterized by the progressive loss of gray matter and/or white matter structures. Drugs CNS stimulants are the class of drugs, producing response to alleviate a particular medical condition. CNS stimulants improve the brain function in patients with schizophrenia and related diseases. CNS stimulants are a class of therapeutic drugs used to treat CNS disorder including the conditions like lack of adrenergic stimulation, symptoms of narcolepsy and neonatal apnea, etc. Apart from drugs, a number of smart tools including Multi-Target Designed Ligands (MTDL) and "predictor" models are contemporarily used to design therapeutic agents for CNS disorders. Mechanism The majority of CNS stimulants causes stimulation of the traditional "fight or flight" syndrome which is concerned with activation of sympathetic nervous system. These neurotransmitters associated receptors are concerned in drug abuse and addiction withdrawal related phenomenon. Conclusion The present review embarks on detail up-to-date information on CNS stimulant drugs, their mechanism of action, in vivo models for biological evaluations with major emphasis on tools in design of therapeutic drugs for CNS disorders.
- Subjects :
- 0301 basic medicine
Sympathetic nervous system
media_common.quotation_subject
medicine.medical_treatment
Central nervous system
Drug Evaluation, Preclinical
01 natural sciences
03 medical and health sciences
Central Nervous System Diseases
Drug Discovery
medicine
Animals
Humans
media_common
business.industry
Mechanism (biology)
Addiction
Brain
General Medicine
medicine.disease
0104 chemical sciences
Stimulant
Substance abuse
010404 medicinal & biomolecular chemistry
030104 developmental biology
medicine.anatomical_structure
Schizophrenia
Drug Design
business
Neuroscience
Narcolepsy
Central Nervous System Agents
Subjects
Details
- ISSN :
- 18744702
- Volume :
- 11
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Current molecular pharmacology
- Accession number :
- edsair.doi.dedup.....ff335f5019984f5caaa684686a95ca47