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Computed tomography-based analyses of baseline body composition parameters and changes in breast cancer patients under treatment with CDK 4/6 inhibitors
- Source :
- Breast Cancer Research and Treatment. 181:199-209
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Body composition parameters including muscle and adipose tissue measurements have emerged as prognostic factors in cancer patients. Besides cell cycle regulation, CDK 4 and 6 also control metabolic processes (lipid synthesis, glycolysis, and mitochondrial function). We studied the impact of baseline body composition parameters on response to CDK 4/6 inhibition and changes on body composition during treatment. Retrospective study of 50 patients treated at Institut Jules Bordet between December 2016 and August 2019 with endocrine therapy and CDK 4/6 inhibitor as first or second-line treatment for metastatic breast cancer (BC). CT-based body composition analysis was performed at 3 time points. Cox regression and Kaplan–Meier method were used for the association with Progression-free survival (PFS). Changes in body composition parameters were described in means and compared using paired sampled T test. Baseline sarcopenia was present in 40% of patients and associated with a significantly worse PFS compared to patients without sarcopenia (20.8 vs 9.6 months, HR 2.52; 95% CI 1.02–6.19, p = 0.037). Patients with higher visceral fat index and higher visceral fat density had better PFS (20.8 vs 10.4 months, HR 0.40; 95% CI 0.16–0.99 p = 0.041-stratified for treatment line). No significant alterations in body composition parameters during treatment were observed. Sarcopenia is a potential early marker of poor prognosis among patients with metastatic BC treated with CDK 4/6 inhibitors. CT scan evaluation of sarcopenia and adiposity revealed significant prognostic information. Visceral fat could also play an important role in response to CDK 4/6 inhibitors, deserving further investigation.
- Subjects :
- Adult
0301 basic medicine
Oncology
Sarcopenia
Cancer Research
medicine.medical_specialty
Antineoplastic Agents, Hormonal
Adipose tissue
Breast Neoplasms
Intra-Abdominal Fat
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Breast cancer
Cyclin-dependent kinase
Internal medicine
Humans
Medicine
Obesity
Neoplasm Metastasis
Aged
Retrospective Studies
Aged, 80 and over
biology
business.industry
Proportional hazards model
Cyclin-Dependent Kinase 4
Cancer
Retrospective cohort study
Cyclin-Dependent Kinase 6
Middle Aged
Prognosis
medicine.disease
Metastatic breast cancer
Survival Rate
030104 developmental biology
Adipose Tissue
030220 oncology & carcinogenesis
Body Composition
biology.protein
Female
Tomography, X-Ray Computed
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15737217 and 01676806
- Volume :
- 181
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....ff3aa11e806324f53e1ea0ae7d9d5947