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A mini-review on quantification of atherosclerosis in hypercholesterolemic mice

Authors :
Hui Chen
Deborah A. Howatt
Michael K. Franklin
Naofumi Amioka
Hisashi Sawada
Alan Daugherty
Hong S. Lu
Source :
Global translational medicine. 1(1)
Publication Year :
2022

Abstract

Atherosclerosis is a leading cause of morbidity and mortality in many countries. Mice are the most frequently used animal model to study the pathogenesis and molecular mechanisms of atherosclerosis. En face analyses of the aorta and cross-sections of the aortic root are the two common modes for quantifying the severity of atherosclerosis in mice. This mini-review introduces these two methods, discusses their pros and cons, and provides suggestions to optimize the quantification of atherosclerosis, thereby enhancing rigor and reproducibility in preclinical research.

Details

Volume :
1
Issue :
1
Database :
OpenAIRE
Journal :
Global translational medicine
Accession number :
edsair.doi.dedup.....ff472675fd7b8d699fbba26f09743c69