Back to Search
Start Over
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index
- Source :
- Hum. Mol. Genet. 25, 389-403 (2016), Human Molecular Genetics, Human Molecular Genetics, 25(2), 389-403. Oxford University Press, Felix, J F, Bradfield, J P, Monnereau, C, van der Valk, R J P, Stergiakouli, E, Chesi, A, Gaillard, R, Feenstra, B, Thiering, E, Kreiner-Møller, E, Blokhuis, M M, Horikoshi, M, Hottenga, J J, Middeldorp, C M, Uitterlinden, A G, Plomin, R, Boomsma, D I, Heinrich, J, Melbye, M, Rivadeneira, F, Hakonarson, H, Ring, S M, Davey Smith, G, Sørensen, T I A, Timpson, N J, Grant, S F A & Jaddoe, V W V 2016, ' Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index ', Human Molecular Genetics, vol. 25, no. 2, pp. 389-403 . https://doi.org/10.1093/hmg/ddv472, Felix, J F, Bradfield, J P, Monnereau, C, Van Der Valk, R J P, Stergiakouli, E, Chesi, A, Gaillard, R, Feenstra, B, Thiering, E, Kreiner-Møller, E, Mahajan, A, Pitk??nen, N, Joro, R, Cavadino, A, Huikari, V, Franks, S, Groen-blokhuis, M M, Cousminer, D L, Marsh, J A, Lehtimäki, T, Curtin, J A, Vioque, J, Ahluwalia, T S, Myhre, R, Price, T S, Vilor-tejedor, N, Yengo, L, Grarup, N, Ntalla, I, Ang, W, Atalay, M, Bisgaard, H, Blakemore, A I, Bonnefond, A, Carstensen, L, Eriksson, J, Flexeder, C, Franke, L, Geller, F, Geserick, M, Hartikainen, A, Haworth, C M A, Hirschhorn, J N, Hofman, A, Holm, J, Horikoshi, M, Hottenga, J J, Huang, J, Kadarmideen, H N, Kähönen, M, Kiess, W, Lakka, H, Lakka, T A, Lewin, A M, Liang, L, Lyytikäinen, L, Ma, B, Magnus, P, Mccormack, S E, Mcmahon, G, Mentch, F D, Middeldorp, C M, Murray, C S, Pahkala, K, Pers, T H, Pfäffle, R, Postma, D S, Power, C, Simpson, A, Sengpiel, V, Tiesler, C M T, Torrent, M, Uitterlinden, A G, Van Meurs, J B, Vinding, R, Waage, J, Wardle, J, Zeggini, E, Zemel, B S, Dedoussis, G V, Pedersen, O, Froguel, P, Sunyer, J, Plomin, R, Jacobsson, B, Hansen, T, Gonzalez, J R, Custovic, A, Raitakari, O T, Pennell, C E, Widøn, E, Boomsma, D I, Koppelman, G H, Sebert, S, Jørvelin, M, Hyppønen, E, Mccarthy, M I, Lindi, V, Harri, N, Kørner, A, Bønnelykke, K, Heinrich, J, Melbye, M, Rivadeneira, F, Hakonarson, H, Ring, S M, Smith, G D, Sørensen, T I A, Timpson, N J, Grant, S F A & Jaddoe, V W V 2015, ' Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index ', Human Molecular Genetics, vol. 25, pp. 389-403 . https://doi.org/10.1093/hmg/ddv472
- Publication Year :
- 2015
-
Abstract
- A large number of genetic loci are associated with adult body mass index. However, the genetics of childhood body mass index are largely unknown. We performed a meta-analysis of genome-wide association studies of childhood body mass index, using sex- and age-adjusted standard deviation scores. We included 35 668 children from 20 studies in the discovery phase and 11 873 children from 13 studies in the replication phase. In total, 15 loci reached genome-wide significance (P-value < 5 × 10−8) in the joint discovery and replication analysis, of which 12 are previously identified loci in or close to ADCY3, GNPDA2, TMEM18, SEC16B, FAIM2, FTO, TFAP2B, TNNI3K, MC4R, GPR61, LMX1B and OLFM4 associated with adult body mass index or childhood obesity. We identified three novel loci: rs13253111 near ELP3, rs8092503 near RAB27B and rs13387838 near ADAM23. Per additional risk allele, body mass index increased 0.04 Standard Deviation Score (SDS) [Standard Error (SE) 0.007], 0.05 SDS (SE 0.008) and 0.14 SDS (SE 0.025), for rs13253111, rs8092503 and rs13387838, respectively. A genetic risk score combining all 15 SNPs showed that each additional average risk allele was associated with a 0.073 SDS (SE 0.011, P-value = 3.12 × 10−10) increase in childhood body mass index in a population of 1955 children. This risk score explained 2% of the variance in childhood body mass index. This study highlights the shared genetic background between childhood and adult body mass index and adds three novel loci. These loci likely represent age-related differences in strength of the associations with body mass index. Refereed/Peer-reviewed
- Subjects :
- 0301 basic medicine
Netherlands Twin Register (NTR)
Male
ADAM23
Genome-wide association study
VARIANTS
ENVIRONMENTAL-FACTORS
Body Mass Index
Child
Genetics (clinical)
2. Zero hunger
Genetics
education.field_of_study
Association Studies Articles
General Medicine
INSIGHTS
Child, Preschool
Female
childhood obesity
EXPRESSION
Adult
Risk
Adolescent
Population
body mass index
Single-nucleotide polymorphism
Biology
ta3111
Polymorphism, Single Nucleotide
Childhood obesity
White People
03 medical and health sciences
Young Adult
children
SDG 3 - Good Health and Well-being
medicine
Humans
Obesity
Allele
education
Molecular Biology
METAANALYSIS
Genetic association
FAT DISTRIBUTION
ta3121
medicine.disease
ta3123
GENE
030104 developmental biology
Genetic Loci
WEIGHT
Body mass index
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 14602083 and 09646906
- Volume :
- 25
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Human molecular genetics
- Accession number :
- edsair.doi.dedup.....ff4904a1e110859cb47db18f25f9c7c0