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Phylogenetics of a Fungal Invasion: Origins and Widespread Dispersal of White-Nose Syndrome
- Source :
- mBio, mBio, American Society for Microbiology, 2017, 8 (6), pp.e01941-17. ⟨10.1128/mBio.01941-17⟩, mBio, 8(6):e01941-17, mBio, Vol 8, Iss 6, p e01941-17 (2017), mBio, Vol 8, Iss 6 (2017)
- Publication Year :
- 2017
- Publisher :
- American Society for Microbiology, 2017.
-
Abstract
- Globalization has facilitated the worldwide movement and introduction of pathogens, but epizoological reconstructions of these invasions are often hindered by limited sampling and insufficient genetic resolution among isolates. Pseudogymnoascus destructans , a fungal pathogen causing the epizootic of white-nose syndrome in North American bats, has exhibited few genetic polymorphisms in previous studies, presenting challenges for both epizoological tracking of the spread of this fungus and for determining its evolutionary history. We used single nucleotide polymorphisms (SNPs) from whole-genome sequencing and microsatellites to construct high-resolution phylogenies of P. destructans . Shallow genetic diversity and the lack of geographic structuring among North American isolates support a recent introduction followed by expansion via clonal reproduction across the epizootic zone. Moreover, the genetic relationships of isolates within North America suggest widespread mixing and long-distance movement of the fungus. Genetic diversity among isolates of P. destructans from Europe was substantially higher than in those from North America. However, genetic distance between the North American isolates and any given European isolate was similar to the distance between the individual European isolates. In contrast, the isolates we examined from Asia were highly divergent from both European and North American isolates. Although the definitive source for introduction of the North American population has not been conclusively identified, our data support the origin of the North American invasion by P. destructans from Europe rather than Asia. IMPORTANCE This phylogenetic study of the bat white-nose syndrome agent, P. destructans , uses genomics to elucidate evolutionary relationships among populations of the fungal pathogen to understand the epizoology of this biological invasion. We analyze hypervariable and abundant genetic characters (microsatellites and genomic SNPs, respectively) to reveal previously uncharacterized diversity among populations of the pathogen from North America and Eurasia. We present new evidence supporting recent introduction of the fungus to North America from a diverse Eurasian population, with limited increase in genetic variation in North America since that introduction.
- Subjects :
- 0301 basic medicine
Pseudogymnoascus destructans
microsatellite
wildlife
Population
Genomics
MESH: Ascomycota
Biology
[SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy
epizootic
Microbiology
03 medical and health sciences
MESH: Mycoses
Phylogenetics
Chiroptera
Virology
Genetic variation
medicine
MESH: Animals
MESH: Communicable Diseases, Emerging
MESH: Genetic Variation
MESH: Phylogeny
education
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Epizootic
Genetic diversity
education.field_of_study
[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE]
MESH: Asia
MESH: Polymorphism, Single Nucleotide
MESH: Chiroptera
MESH: Nose
emerging infectious disease
MESH: Population Dynamics
medicine.disease
QR1-502
MESH: North America
030104 developmental biology
Genetic distance
whole-genome sequencing
Evolutionary biology
Biological dispersal
MESH: Europe
MESH: Microsatellite Repeats
[SDE.BE]Environmental Sciences/Biodiversity and Ecology
MESH: Whole Genome Sequencing
infectious
disease
whole-genome
destructans
Pseudogymnoascus
emerging
sequencing
Subjects
Details
- ISSN :
- 21507511 and 21612129
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- mBio
- Accession number :
- edsair.doi.dedup.....ff502c57424cdf83719131e8706b732f
- Full Text :
- https://doi.org/10.1128/mbio.01941-17