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Effect of Qingfei Paidu decoction combined with Western medicine treatments for COVID-19: A systematic review and meta-analysis

Authors :
Lei Zhang
Yan Ma
Nannan Shi
Lin Tong
Sihong Liu
Xinyu Ji
Renbo Chen
Yipin Fan
Ning Liang
Youwen Ge
Hongjie Gao
Guangkun Chen
Wei Wang
Huamin Zhang
Yanping Wang
Yongyan Wang
Source :
Phytomedicine : international journal of phytotherapy and phytopharmacology. 102
Publication Year :
2022

Abstract

Qingfei Paidu decoction (QFPDD) showed to be beneficial for the treatment of coronavirus disease 2019 (COVID-19) in China.This study aimed to systematically assemble the evidence on the efficacy and safety of QFPDD combined with Western medicine treatments (WMT) for COVID-19.Systematic review and meta-analysis.A comprehensive literature search was conducted in PubMed, Embase, Cochrane Library, CNKI, CSTJ, CBM, Wanfang Data for clinical trials with a control arm until January 13, 2022. Studies matched the selection criteria were included. Data extraction and quality assessment of the included studies were independently conducted by two reviewers. Review Manager 5.4 was used for meta-analysis.A total of 9 trials including 1108 COVID-19 patients met the selection criteria. Meta-analysis demonstrated that QFPDD combined with WMT reduced aggravation rate (AR) by 71% [risk ratio (RR) = 0.29, 95% confidence intervals (CI) (0.17, 0.51)], increased effective rate (ER) by 13% [RR = 1.13, 95%CI (1.04, 1.22)], shortened 4.78 days of viral shedding [95%CI (-5.79, -3.77)] and 4.45 days of hospital stay [95%CI (-6.05, -2.86)], also decreased the incidence of adverse events (AE) by 56% [RR = 0.44, 95%CI (0.22, 0.89)].QFPDD combined with WMT might reduce the proportion of severe cases and the incidence of AE, shorten the duration of viral shedding and length of hospital stay. More randomized controlled trials (RCTs) are required to confirm our findings in the future.

Details

ISSN :
1618095X
Volume :
102
Database :
OpenAIRE
Journal :
Phytomedicine : international journal of phytotherapy and phytopharmacology
Accession number :
edsair.doi.dedup.....ff64903496b1b1662a9d963b9c1cc9be