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Imatinib-induced Gastrointestinal Vascular Ectasia in a Patient with Advanced GIST: Case Report and Literature Review
- Source :
- Anticancer Research. 36:6151-6154
- Publication Year :
- 2016
- Publisher :
- Anticancer Research USA Inc., 2016.
-
Abstract
- BACKGROUND Imatinib is generally well tolerated in the treatment of advanced gastrointestinal stromal tumors (GIST). Gastrointestinal vascular ectasia (GIVE) and gastric antral vascular ectasia (GAVE), while rare, are significant under-reported complications of imatinib therapy. CASE REPORT We present one patient with GIVE complicating imatinib therapy with a literature review of this rare side-effect. RESULTS A 68-year-old woman was diagnosed with advanced GIST, wild-type CKIT. After 3 months of treatment with imatinib, she had partial response. However, she was diagnosed with GAVE and, later, also with GIVE. During her 3-year imatinib treatment, she suffered from severe anemia and required blood transfusions. Conservative treatments were not helpful and the ectatic lesions resolved only with cessation of imatinib. CONCLUSION This confirms a causal relationship between GIVE and imatinib. GIVE and GAVE should be considered possible causes of anemia and upper gastrointestinal bleeding in patients receiving imatinib therapy.
- Subjects :
- Cancer Research
medicine.medical_specialty
Gastrointestinal Stromal Tumors
Anemia
Antineoplastic Agents
Imatinib therapy
Multimodal Imaging
Gastroenterology
Imatinib treatment
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Internal medicine
Ectasia
medicine
Humans
neoplasms
Aged
GiST
business.industry
Gastric antral vascular ectasia
Imatinib
General Medicine
medicine.disease
Surgery
Oncology
Positron-Emission Tomography
030220 oncology & carcinogenesis
Imatinib Mesylate
Female
030211 gastroenterology & hepatology
Upper gastrointestinal bleeding
Tomography, X-Ray Computed
business
Gastric Antral Vascular Ectasia
medicine.drug
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....ff681cc0780eb04dbe7d13356a20c3fd