Back to Search Start Over

COVID-19 in CKD Patients : Lessons from 553 CKD Patients with Biopsy-Proven Kidney Disease

Authors :
María José Soler
Nestor Toapanta
Daniel Serón
Cinthia Baldallo
Irene Agraz
Clara García-Carro
Roxana Bury
Alejandra Gabaldon
Juan Carlos León Román
Ander Vergara
Irina B. Torres
Institut Català de la Salut
[Román JL, García-Carro C, Agraz I, Toapanta N, Torres I, Bury R, Baldallo C] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Vergara A] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Grup de Recerca en Nefrologia, Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Gabaldón A] Servei de Patologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Serón D, Soler MJ] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Grup de Recerca en Nefrologia, Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Instituto Carlos IIIFEDER, Red de Investigación Renal (REDINREN), Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
Source :
Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Kidney & Blood Pressure Research, Scientia, Kidney & Blood Pressure Research, Pp 1-8 (2021)
Publication Year :
2021

Abstract

Introduction: Chronic kidney disease (CKD) patients infected with COVID-19 are at risk of serious complications such as hospitalization and death. The prognosis and lethality of COVID-19 infection in patients with established kidney disease has not been widely studied. Methods: Data included patients who underwent kidney biopsy at the Vall d’Hebron Hospital between January 2013 and February 2020 with COVID-19 diagnosis during the period from March 1 to May 15, 2020. Results: Thirty-nine (7%) patients were diagnosed with COVID-19 infection. Mean age was 63 ± 15 years and 48.7% were male. Hypertension was present in 79.5%, CKD without renal replacement therapy in 76.9%, and cardiovascular disease in 64.1%. Nasopharyngeal swab was performed in 26 patients; older (p = 0.01), hypertensive (p = 0.005), and immunosuppressed (p = 0.01) patients, those using RAS-blocking drugs (p = 0.04), and those with gastrointestinal symptoms (p = 0.02) were more likely to be tested for CO­VID-19. Twenty-two patients required hospitalization and 15.4% died. In bivariate analysis, mortality was associated with older age (p = 0.03), cardiovascular disease (p = 0.05), chronic obstructive pulmonary disease (p = 0.05), and low hemoglobin levels (p = 0.006). Adjusted Cox regression showed that low hemoglobin levels at admission had 1.81 greater risk of mortality. Conclusions: Patients with CO­VID-19 infection and kidney disease confirmed by kidney biopsy presented a mortality of 15.4%. Swab test for COVID-19 was more likely to be performed in older, hypertensive, and immunosuppressed patients, those using RAS-blocking drugs, and those with gastrointestinal symptoms. Low hemoglobin is a risk factor for mortality.

Subjects

Subjects :
Male
Biopsy
medicine.medical_treatment
Disease
Fetge - Càncer - Tractament
Renin-Angiotensin System
Hemoglobins
Pulmonary Disease, Chronic Obstructive
Chronic kidney disease
virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES]
Risk of mortality
Severe acute respiratory syndrome coronavirus 2
COVID-19 (Malaltia) - Complicacions
Aged, 80 and over
Kidney
medicine.diagnostic_test
Age Factors
Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES]
Immunosuppression
General Medicine
Middle Aged
Prognosis
Hospitalization
Renal Replacement Therapy
medicine.anatomical_structure
Cardiovascular Diseases
Nephrology
RL1-803
Hypertension
Female
Cardiology and Cardiovascular Medicine
Research Article
terapéutica::tratamiento de reemplazo renal [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS]
medicine.medical_specialty
Dermatology
Therapeutics::Renal Replacement Therapy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT]
Internal medicine
medicine
Diseases of the circulatory (Cardiovascular) system
Humans
Renal replacement therapy
Renal Insufficiency, Chronic
Risk factor
Aged
Immunosuppression Therapy
Fetge - Malalties - Biòpsia
business.industry
Male Urogenital Diseases::Urologic Diseases::Kidney Diseases [DISEASES]
COVID-19
medicine.disease
Diseases of the genitourinary system. Urology
Coronavirus
Biopsy-proven kidney disease
RC666-701
RC870-923
business
enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales [ENFERMEDADES]
Kidney disease

Details

Database :
OpenAIRE
Journal :
Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, Kidney & Blood Pressure Research, Scientia, Kidney & Blood Pressure Research, Pp 1-8 (2021)
Accession number :
edsair.doi.dedup.....ff6a641a7edc11e6df70802ea07c17b1