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The role of exosome lipids in central nervous system diseases
- Source :
- Reviews in the Neurosciences. 31:743-756
- Publication Year :
- 2020
- Publisher :
- Walter de Gruyter GmbH, 2020.
-
Abstract
- Central nervous system (CNS) diseases are common diseases that threaten human health. The CNS is highly enriched in lipids, which play important roles in maintaining normal physiological functions of the nervous system. Moreover, many CNS diseases are closely associated with abnormal lipid metabolism. Exosomes are a subtype of extracellular vesicles (EVs) secreted from multivesicular bodies (MVBs) . Through novel forms of intercellular communication, exosomes secreted by brain cells can mediate inter-neuronal signaling and play important roles in the pathogenesis of CNS diseases. Lipids are essential components of exosomes, with cholesterol and sphingolipid as representative constituents of its bilayer membrane. In the CNS, lipids are closely related to the formation and function of exosomes. Their dysregulation causes abnormalities in exosomes, which may, in turn, lead to dysfunctions in inter-neuronal communication and promote diseases. Therefore, the role of lipids in the treatment of neurological diseases through exosomes has received increasing attention. The aim of this review is to discuss the relationship between lipids and exosomes and their roles in CNS diseases.
- Subjects :
- 0301 basic medicine
Nervous system
Central nervous system
Cell Communication
Biology
Exosomes
Exosome
Pathogenesis
Extracellular Vesicles
03 medical and health sciences
0302 clinical medicine
Central Nervous System Diseases
medicine
Humans
General Neuroscience
Lipid metabolism
Lipid Metabolism
Lipids
Sphingolipid
Microvesicles
Cell biology
030104 developmental biology
medicine.anatomical_structure
lipids (amino acids, peptides, and proteins)
030217 neurology & neurosurgery
Function (biology)
Subjects
Details
- ISSN :
- 21910200 and 03341763
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Reviews in the Neurosciences
- Accession number :
- edsair.doi.dedup.....ff7b92857cb4b0c38fbc27ecdbdd5830