ANTICANCER ACTIVITIES OF EVEN NUMBERED MONOKETO EICOSANOIC ACID ANILIDES AND SEMICARBAZONES

Authors :: Tülay Bakirel
Hülya Çelik Onar
Hasniye Yaşa
Fatma Ceren Anlaş
Belma Hasdemir
Fulya Üstün Alkan
Source :: Volume: 6, Issue: 3 429-432, Journal of the Turkish Chemical Society Section A: Chemistry
Publication Year :: 2019
Publisher :: The Turkish Chemical Society, 2019.
Abstract: This study was undertaken to examine the possible cytotoxic effect of anilide and semicarbazone derivatives of (4-12) monoketo eicosanoic acids (3.125 – 100 µM) on canine mammary tumour cell line (CMT-U27) as compared with doxorubicin. Among these compounds, 8-semicarbazone eicosanoic acid (3) and 10-keto eicosanoic acid anilide (9) displayed effective cytotoxic potential against CMT-U27 and IC50 concentrations were recorded at 1.952 µM and 54.00 µM, respectively.

Subjects :: Chemistry
Stereochemistry
Chemistry, Multidisciplinary
General Chemistry
Anilide,Semicarbazone,Fatty Acid,Canine mammary tumor
Mammary tumour
chemistry.chemical_compound
Cell culture
medicine
Cytotoxic T cell
Doxorubicin
Kimya, Ortak Disiplinler
Semicarbazone
Eicosanoic Acids
medicine.drug

Full Text Access

Tools