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Is high vitamin B12 status a cause of lung cancer?

Authors :
Alan A. Arslan
Woon-Puay Koh
Ben Michael Brumpton
Stig E. Bojesen
Mark P. Purdue
Neil E. Caporaso
William J. Blot
Yong-Bing Xiang
Allison M. Hodge
Meir J. Stampfer
Jonas Manjer
Tricia L Larose
I-Min Lee
Gianluca Severi
Robert Carreras-Torres
Rayjean J. Hung
Mikael Johansson
J. Michael Gaziano
Julie E. Buring
Christopher A. Haiman
Per Magne Ueland
S. M. Arnold
Paul Brennan
Qing Lan
Qiuyin Cai
Honglan Li
Howard D. Sesso
Renwei Wang
Kala Visvanathan
Loic Le Marchand
Ulrika Ericson
Edward Giovannucci
Ross L. Prentice
Anouar Fanidi
Christopher I. Amos
Yu-Tang Gao
Demetrius Albanes
Judith Hoffman-Bolton
Xiao-Ou Shu
Caroline L Relton
Stephanie A. Smith-Warner
Mattias Johansson
Jian-Min Yuan
Graham G. Giles
Wei Zheng
Stephanie J. Weinstein
Arnulf Langhammer
Kjell Grankvist
Anne Zeleniuch-Jacquotte
Xuehong Zhang
Neal D. Freedman
Lynne R. Wilkens
Victoria L. Stevens
Øivind Midttun
Mary Pettinger
Marjorie L. McCullough
Source :
2019, ' Is high vitamin B12 status a cause of lung cancer? ', International Journal of Cancer, vol. 145, no. 6, pp. 1499-1503 . https://doi.org/10.1002/ijc.32033
Publication Year :
2019
Publisher :
Wiley, 2019.

Abstract

Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer aetiology via direct measurements of pre‐diagnostic circulating vitamin B12 concentrations in a nested case‐control study, complemented with a Mendelian randomization (MR) approach in an independent case‐control sample. We used pre‐diagnostic biomarker data from 5,183 case‐control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls.Exposures included directly measured circulating vitamin B12 in pre‐diagnostic blood samples from the nested case‐control study, and 8 single nucleotide polymorphisms associated with vitamin B12 concentrations in the MR study.Our main outcome of interest was increased risk for lung cancer, overall and by histological subtype, per increase in circulating vitamin B12 concentrations.We found circulating vitamin B12 to be positively associated with overall lung cancer risk in a dose response fashion (odds ratio for a doubling in B12 [ORlog2B12] = 1.15, 95% confidence interval (95%CI) = 1.06‐1.25). The MR analysis based on 8 genetic variants also indicated that genetically determined higher vitamin B12 concentrations were positively associated with overall lung cancer risk (OR per 150 pmol/L standard deviation increase in B12 [ORSD]= 1.08, 95%CI= 1.00‐1.16).Considering the consistency of these two independent and complementary analyses, these findings support the hypothesis that high vitamin B12 status increases the risk of lung cancer.

Details

ISSN :
10970215 and 00207136
Volume :
145
Database :
OpenAIRE
Journal :
International Journal of Cancer
Accession number :
edsair.doi.dedup.....ff93294e235a5801e476a8bec205dd45